pentylphosphonic acid dibutyl ester | 995-48-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: pentylphosphonic acid dibutyl ester
• 英文别名: Pentan-phosphonsaeure-(1)-dibutylester；Pentyl-phosphonsaeure-dibutylester；Pentylphosphonsaeure-dibutylester；1-Dibutoxyphosphorylpentane
• CAS: 995-48-2
• 化学式: C₁₃H₂₉O₃P
• 分子量: 264.345
• InChiKey: DNQUCFAIFMXLHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  pentylphosphonic acid dibutyl ester 生成 (1-nitro-pentyl)-phosphonic acid dibutyl ester
  参考文献：
  名称：

  Alkyl nitrate nitration of active methylene compounds. 14. Nitration of alkylphosphonate esters

  摘要：

  DOI：

  10.1021/jo00418a039
• 作为产物：
  描述：

  1-溴戊烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 正己烷 作用下， 生成 pentylphosphonic acid dibutyl ester
  参考文献：
  名称：

  The Aqueous Solubility of Acetanilide

  摘要：

  DOI：

  10.1021/ja01223a046

文献信息

• US2397422
  申请人：——

  公开号：——

  公开（公告）日：——
• Eotaxin Expression by Epithelial Cells and Plasma Cells in Chronic Asthma
  作者：Rakesh K Kumar、Paul S Thomas、Da-Qiang Seetoo、Cristan Herbert、Andrew N J McKenzie、Paul S Foster、Andrew R Lloyd

  DOI：10.1038/labinvest.3780442

  日期：2002.4

  Chemoattractants such as eotaxin are believed to play an important role in the recruitment of eosinophils into the airways in asthma. We investigated expression of eotaxin in the airway wall in a model of chronic human asthma, in which systemically sensitized mice were exposed to low mass concentrations of aerosolized antigen for 6 weeks. In these animals, the number of intraepithelial eosinophils in the airways was significantly increased 3 hours after exposure and declined by 24 hours. In parallel, immunoreactivity for eotaxin was strikingly up-regulated in airway epithelial cells and in inflammatory cells in the lamina propria. The latter were identified as plasma cells by double immunofluorescent labeling. Increased expression of eotaxin by epithelial cells and plasma cells was also demonstrated in a case of fatal human asthma. In contrast, sensitized mice that received a single exposure to a high mass concentration of aerosolized antigen exhibited delayed eosinophil recruitment, which did not correlate with eotaxin expression. Furthermore, in sensitized chronically exposed interieukin-13-deficient mice there was virtually no recruitment of eosinophils into the airways, although eotaxin expression was greater than or equal to that in wild-type mice. These results indicate that there are striking differences between acute and chronic exposure models in the time course of eotaxin expression and eosinophil recruitment. Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis.
• Bogonostseva,N.P.; Filippova,T.E., Journal of general chemistry of the USSR, 1963, vol. 33, p. 1332 - 1334
  作者：Bogonostseva,N.P.、Filippova,T.E.

  DOI：——

  日期：——
• Alkyl nitrate nitration of active methylene compounds. 14. Nitration of alkylphosphonate esters
  作者：H. Feuer、W. D. Van Buren、John B. Grutzner

  DOI：10.1021/jo00418a039

  日期：1978.11
• The Aqueous Solubility of Acetanilide
  作者：Thomas S. Logan

  DOI：10.1021/ja01223a046

  日期：1945.7