3-chloro-4,N-dihydroxy-5-methoxybenzamidine | 944327-01-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-chloro-4,N-dihydroxy-5-methoxybenzamidine
• 英文别名: 3-chloro-N',4-dihydroxy-5-methoxybenzenecarboximidamide
• CAS: 944327-01-9
• 化学式: C₈H₉ClN₂O₃
• 分子量: 216.624
• InChiKey: ZPTTYHVLBBFOAA-UHFFFAOYSA-N

物化性质

• 沸点：
  365.8±52.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  88.1
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-羟基-2-甲氧基苯甲醛 、 3-chloro-4,N-dihydroxy-5-methoxybenzamidine 生成 4,N-dihydroxy-3-methoxy-5-methylbenzamidine
  参考文献：
  名称：

  Pyridin-4-yl derivatives as immunomodulating agents

  摘要：

  本发明涉及式（I）的吡啶衍生物，其中A，R1，R2，R3，R4，R5和R6如描述中所述，它们的制备以及它们作为药物活性化合物的用途。所述化合物特别作为免疫调节剂。

  公开号：

  US08580824B2
• 作为产物：
  描述：

  5-氯香草醛 生成 3-chloro-4,N-dihydroxy-5-methoxybenzamidine
  参考文献：
  名称：

  WO2008/29371

  摘要：

  公开号：

文献信息

• AMINO-PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS
  申请人：Bolli Martin

  公开号：US20100087417A1

  公开（公告）日：2010-04-08

  The invention relates to novel amino-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及新型氨基吡啶衍生物，其制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• Pyridin-3-yl derivatives as immunomodulating agents
  申请人：Bolli Martin

  公开号：US20100168005A1

  公开（公告）日：2010-07-01

  The invention relates to pyridin-3-yl derivatives of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 ; R 6 and A are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及Formula (I)中的吡啶-3-基衍生物，其中R1、R2、R3、R4、R5、R6和A如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• [EN] 2-METHOXY-PYRIDIN-4-YL DERIVATIVES<br/>[FR] DÉRIVÉS DE 2-METHOXY-PYRIDIN-4-YL
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2012098505A1

  公开（公告）日：2012-07-26

  The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及式（I）的吡啶衍生物，其中A、R1、R2、R3和R4如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• 2-METHOXY-PYRIDIN-4-YL-DERIVATIVES
  申请人：Bolli Martin

  公开号：US20130303514A1

  公开（公告）日：2013-11-14

  The invention relates to pyridine derivatives of Formula (I) wherein A, R 1 , R 2 , R 3 , and R 4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及公式（I）中的吡啶衍生物，其中A、R1、R2、R3和R4如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• NOVEL THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS
  申请人：Boli Martin

  公开号：US20100240717A1

  公开（公告）日：2010-09-23

  The invention relates to thiophene derivatives of formula (I)/their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents wherein: A represents *—CO—CH═CH—, *—CO—CH 2 CH 2 —, *—CO—CH 2 —NH—, wherein the sterisks indicate the bond that is linked to the thiophene group of Formula (I), and R1-R3 are as defined in the claims.

  本发明涉及公式（I）的噻吩衍生物/它们的制备及其作为药物活性化合物的用途。所述化合物特别作为免疫抑制剂，其中：A代表*—CO—CH═CH—、*—CO— —、*—CO—CH2—NH—，其中星号表示与公式（I）的噻吩基团相连的键，R1-R3如权利要求所定义。