4-(4-bromo-1H-pyrazol-1-yl)-1lambda6-thiane-1,1-dione | 1782408-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: 4-(4-bromo-1H-pyrazol-1-yl)-1lambda6-thiane-1,1-dione
• 英文别名: 4-(4-bromopyrazol-1-yl)thiane 1,1-dioxide
• CAS: 1782408-09-6
• 化学式: C₈H₁₁BrN₂O₂S
• 分子量: 279.16
• InChiKey: VWXKUVNQVOUBBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES<br/>[FR] COMPOSÉS DE PYRROLOTRIAZINE ET PROCÉDÉS D'INHIBITION DE KINASES TAM
  申请人：SYROS PHARMACEUTICALS INC

  公开号：WO2019074962A1

  公开（公告）日：2019-04-18

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat cancer. (II), or a pharmaceutically acceptable salt thereof, wherein: R1 is pyridin-3-yl, pyridin-4-yl, pyrazol-4-yl, cyclohexyl, or 8-azabicyclo[3.2.1]oct-2- ene-3-yl, wherein R1 is optionally substituted with up to four independently selected substituents; R2 is cyclohexyl substituted with hydroxy and optionally substituted with one or two additional substituents independently selected from C1-C4 alkyl and fluoro, or is 4,5,6,7- tetrahydro-lH-indazolyl optionally substituted with one to three substituents independently selected from C1-C4 alkyl and fluoro; and R3 is -C3-C8 alkyl, -(C2-C6 alkylene)-0-(C1-C6 alkyl), C3-C6 cycloalkyl, or -(C2-C6 alkylene)-C3-C6 cycloalkyl, wherein R3 is optionally substituted with 1-5 substituents inde endentl selected from deuterium, halo, and -OH.

  本文描述了化合物、制备这种化合物的方法、含有这种化合物的药物组合物和药物，以及使用这种化合物治疗癌症的方法。其中，R1为吡啶-3-基、吡啶-4-基、吡唑-4-基、环己基或8-氮杂双环[3.2.1]辛-2-烯-3-基，其中R1可选择性地与最多四个独立选择的取代基取代；R2为环己基，其与羟基取代，并可选择性地与一个或两个额外的独立选择的来自C1-C4烷基和氟的取代基取代，或者为4,5,6,7-四氢-1H-吲哚基，可选择性地与一个至三个独立选择的来自C1-C4烷基和氟的取代基取代；R3为-C3-C8烷基、-(C2-C6烷基)-O-(C1-C6烷基)、C3-C6环烷基或-(C2-C6烷基)-C3-C6环烷基，其中R3可选择性地与1-5个独立选择的氘、卤素和-OH取代。
• Pyrrolotriazine compounds and methods of inhibiting TAM kinases
  申请人：Syros Pharmaceuticals, Inc.

  公开号：US11040981B2

  公开（公告）日：2021-06-22

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat cancer.

  本文描述的是化合物、制造此类化合物的方法、药物组合物、包含此类化合物的药物，以及使用此类化合物治疗癌症的方法。
• PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES
  申请人：Syros Pharmaceuticals, Inc.

  公开号：US20200317676A1

  公开（公告）日：2020-10-08

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat cancer.