| 1356133-59-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1356133-59-9
• 化学式: C₁₇H₁₀F₄O
• 分子量: 306.259
• InChiKey: XOQNOFZOHYTZCL-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 在 偶氮二甲酸二异丙酯 、 N,N-二异丙基乙胺 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以25%的产率得到
  参考文献：
  名称：

  Acid-facilitated debenzylation of N-Boc, N-benzyl double protected 2-aminopyridinomethyl pyrrolidine derivatives

  摘要：

  2-Aminopyridinomethyl pyrrolidines represent a class of highly potent and selective neuronal nitric oxide synthase inhibitors. Conditions for a Mitsunobu reaction of a naphthol and a hindered secondary alcohol were optimized to give good to excellent yields. A key step in the synthesis of these inhibitors is the deprotection of the benzyl group from the N-Boc and N-Bn double protected 2-aminopyridine ring at a late stage of the synthesis, which has been proven difficult in our previous syntheses. Acetic acid was found to facilitate the N-Bn deprotection. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.12.013