5-(4-Propylamino-phenyl)-[1,3,4]thiadiazol-2-ylamine | 3121-67-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-(4-Propylamino-phenyl)-[1,3,4]thiadiazol-2-ylamine
• 英文别名: 1,3,4-Thiadiazol-2-amine,5-[4-(propylamino)phenyl]-；5-[4-(propylamino)phenyl]-1,3,4-thiadiazol-2-amine
• CAS: 3121-67-3
• 化学式: C₁₁H₁₄N₄S
• 分子量: 234.325
• InChiKey: BLTGZFBYUSVQRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  92.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES<br/>[FR] DÉRIVÉS DE NAPHTALIMIDE SERVANT D'AGENTS ANTIPARASITAIRES POUR LE TRAITEMENT DE LA LEISHMANIOSE ET DE MALADIES VIRALES, BACTÉRIENNES ET NÉOPLASIQUES
  申请人：UNIV ISTANBUL MEDIPOL

  公开号：WO2020139291A1

  公开（公告）日：2020-07-02

  The present patent application discloses naphthalimide derivatives and in particular e.g. N-aryl-substituted naphthalimidopropylamine derivatives (i.e. 2-[3-(amino)propyl]-1H-benz[de]isoquinoline-1,3(2H)- dione derivatives) such as e.g. such as e.g.(Formula I) or (Formula III) as anti-parasitic agents for the treatment of Leishmaniasis. The compounds could also be useful to treat viral, bacterial and/or neoplastic diseases. The description discloses exemplary synthesis as well as biological tests against Leishmania Infantum parasites (e.g. pages 54 to 58; examples 1 to 7). Exemplary compounds are:(example 3)(example 4) 2-(3-((5-amino naphtha lene-l-yl)amino)propyl)-lH-benzo[de]isoq uinoline-1, 3(2 H)-dione (example 5) 2-(3-((5-amino naphtha lene-l-yl)amino)propyl)-lH-benzo[de]isoq uinoline-1, 3(2 H)-dione (example 6)

  本专利申请公开了萘酰亚胺衍生物，特别是例如N-芳基取代的萘酰亚胺丙胺衍生物（即2-[3-(氨基)丙基]-1H-苯并[de]异喹啉-1,3(2H)-二酮衍生物），例如（公式I）或（公式III），作为治疗利什曼病的抗寄生虫剂。这些化合物也可能对治疗病毒、细菌和/或肿瘤疾病有用。本说明书公开了示例性的合成方法以及针对Leishmania Infantum寄生虫的生物测试（例如第54至58页；示例1至7）。示例化合物包括：（示例3）（示例4）2-(3-((5-氨基萘-1-基)氨基)丙基)-1H-苯并[de]异喹啉-1,3(2H)-二酮（示例5）2-(3-((5-氨基萘-1-基)氨基)丙基)-1H-苯并[de]异喹啉-1,3(2H)-二酮（示例6）。
• NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES
  申请人：ISTANBUL MEDIPOL UNIVERSITESI

  公开号：US20220143005A1

  公开（公告）日：2022-05-12

  Disclosed are naphthalimide derivatives and in particular e.g. N-aryl-substituted naphthalimidopropylamine derivatives (i.e. 2-[3-(amino)propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione derivatives) such as e.g. such as e.g. (Formula I) or (Formula III) as anti-parasitic agents for the treatment of Leishmaniasis. The compounds could also be useful to treat viral, bacterial and/or neoplastic diseases. The description discloses exemplary synthesis as well as biological tests against Leishmania infantum parasites (e.g. pages 54 to 58; examples 1 to 7). Exemplary compounds are: (example 3)(example 4) 2-(3-((5-amino naphthalene-1-yl)amino)propyl)-1H-benzo[de]isoquinoline-1, 3(2H)-dione (example 5) 2-(3-((5-amino naphthalene-1-yl)amino)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (example 6).