8-methoxy-2H-chromene-4-carboxylic acid | 853926-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-methoxy-2H-chromene-4-carboxylic acid
• 英文别名: 8-Methoxy-2H-chromen-4-carbonsaeure；8-methoxy-2H-chromene-4-carboxylic acid
• CAS: 853926-28-0
• 化学式: C₁₁H₁₀O₄
• 分子量: 206.198
• InChiKey: LADJUCSRSKGMSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-methoxy-2H-chromene-4-carboxylic acid 在 吡啶 、 氢氟酸 作用下， 生成 (2,4-diacetoxy-3-isopentyl-phenyl)-(8-methoxy-2H-chromen-4-yl)-ketone
  参考文献：
  名称：

  Offe; Barkow, Chemische Berichte, 1947, vol. 80, p. 464,467

  摘要：

  DOI：
• 作为产物：
  描述：

  8-methoxy-3-oxo-chroman-4-carboxylic acid ethyl ester 在 氢氧化钾 、 乙醇 、 铂 作用下， 生成 8-methoxy-2H-chromene-4-carboxylic acid
  参考文献：
  名称：

  O'Donnell et al., Journal of the Chemical Society, 1936, p. 419,422

  摘要：

  DOI：

文献信息

• AMIDES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1581476B1

  公开（公告）日：2016-11-16
• ADAMANTYL ACETAMIDES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS
  申请人：Linders Theodorus Maria Joannes

  公开号：US20080096869A1

  公开（公告）日：2008-04-24

  the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R 1 and R 2 each independently represents hydrogen C 1-4 alkyl, NR 9 R 10 , C 1-4 alkyloxy; or R 1 and R 2 taken together with the carbon atom with which they are attached form a C 3-6 cycloalkyl; and where n is 2, either R 1 or R 2 may be absent to form an unsaturated bond; R 3 represents a C 6-12 cycloalkyl, preferably selected from cylo-octanyl and cyclohexyl or R 3 represents a monovalent radical having one of the following formulae wherein said C 6-12 cycloalkyl or monovalent radical may optionally be substituted with one, or where possible two, three or more substituents selected from the group consisting of C 1-4 alkyl, C 1-4 alkyloxy, halo or hydroxy; Q represents Het 1 or Ar 2 wherein said C 3-8 cycloalkyl, Het 1 or Ar 2 are optionally substituted with one or where possible two or more substituents selected from halo, C 1-4 alkyl, C 1-4 alkyloxy, hydroxy, nitro, NR 5 R 6 , C 1-4 alkyloxy substituted with one or where possible two, three or more substituents each independently selected from hydroxycarbonyl, Het 2 and NR 7 R 8 , and C 1-4 alkyl substituted with one or where possible two or three halo substituents, preferably trifluoromethyl; R 5 and R 6 each independently represent hydrogen, C 1-4 alkyl, or C 1-4 alkyl substituted with phenyl; R 7 and R 8 each independently represent hydrogen or C 1-4 alkyl; R 9 and R 10 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkyloxycarbonyl; L represents C 1-4 alkyl; Het 1 represents a heterocycle selected from pyridinyl, thiophenyl, or 1,3-benzodioxolyl; Het 2 represents piperidinyl, pyrrolidinyl or morpholinyl; Ar 2 represents phenyl, naphtyl or indenyl.
• US7332524B2
  申请人：——

  公开号：US7332524B2

  公开（公告）日：2008-02-19
• US7968601B2
  申请人：——

  公开号：US7968601B2

  公开（公告）日：2011-06-28
• Offe; Barkow, Chemische Berichte, 1947, vol. 80, p. 464,467
  作者：Offe、Barkow

  DOI：——

  日期：——