4-isopropyl-cinnoline | 46161-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-isopropyl-cinnoline
• 英文别名: 4-Propan-2-ylcinnoline
• CAS: 46161-92-6
• 化学式: C₁₁H₁₂N₂
• 分子量: 172.23
• InChiKey: FFRNNWAUVODAKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 5, 6-RING ANNULATED INDOLE DERIVATIVES AND USE THEREOF
  申请人：Bennett Frank

  公开号：US20100322901A1

  公开（公告）日：2010-12-23

  The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

  本发明涉及公式（I）的5,6-环接合吲哚衍生物，包含至少一种5,6-环接合吲哚衍生物的组合物，以及利用这些5,6-环接合吲哚衍生物治疗或预防患者病毒感染或与病毒相关的疾病的方法。
• METALLOENZYME INHIBITOR COMPOUNDS
  申请人：Viamet Pharmaceuticals (NC), Inc.

  公开号：US20180185362A1

  公开（公告）日：2018-07-05

  Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

  提供具有金属酶调节活性的化合物，以及通过这些金属酶介导的治疗疾病、紊乱或症状的方法。
• PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE
  申请人：Castanedo Georgette

  公开号：US20110207713A1

  公开（公告）日：2011-08-25

  Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

  Formula I 化合物，包括立体异构体、几何异构体、互变异构体、代谢物及其药学上可接受的盐，对抑制 PI3K 的δ异构体以及治疗由脂质激酶介导的疾病，如炎症、免疫性疾病和癌症，具有用途。公开了利用 Formula I 化合物在哺乳动物细胞中进行体外、体内和体内诊断、预防或治疗此类疾病，或相关病理条件的方法。
• AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES
  申请人：ChemoCentryx, Inc.

  公开号：US20130225580A1

  公开（公告）日：2013-08-29

  Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.

  提供的化合物作为CCR(9)受体的有效拮抗剂。动物实验表明，这些化合物对于治疗CCR(9)引起的炎症非常有效。这些化合物通常是芳基磺酰胺衍生物，可用于制药组合物、治疗CCR(9)介导的疾病的方法，以及作为鉴定CCR(9)拮抗剂的检测中的对照物。
• DIOXINO- AND OXAZIN-[2,3-D]PYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
  申请人：Genentech, Inc.

  公开号：US20140065136A1

  公开（公告）日：2014-03-06

  Dioxino- and oxazin-[2,3-d]pyrimidine PI3K inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions.

  公式I中的二氧代二氧代噁唑啉和噁唑啉[2,3-d]嘧啶PI3K抑制剂化合物具有抗癌活性、抗炎活性或免疫调节性质，更具体地具有PI3激酶调节或抑制活性。描述了使用公式I中的三环PI3K抑制剂化合物的方法，用于体外、体内和体内对哺乳动物细胞、生物体或相关病理条件进行诊断或治疗。