N-(3-(4-amino-2-(3,4,5-trimethoxyphenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)benzo[b]thiophen-2-carboxamide | 1308690-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-(3-(4-amino-2-(3,4,5-trimethoxyphenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)benzo[b]thiophen-2-carboxamide
• 英文别名: N-[3-[4-amino-2-(3,4,5-trimethoxyanilino)thieno[3,2-d]pyrimidin-7-yl]phenyl]-1-benzothiophene-2-carboxamide
• CAS: 1308690-09-6
• 化学式: C₃₀H₂₅N₅O₄S₂
• 分子量: 583.692
• InChiKey: IJCLOPHLFXRWLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  177
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• 2,4,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
  申请人：Sim Tae Bo

  公开号：US20130012703A1

  公开（公告）日：2013-01-10

  Disclosed are a 2,4,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,4,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.

  揭示了一种具有蛋白激酶抑制活性的2,4,7-取代噻吩[3,2-d]嘧啶化合物，以及一种药学上可接受的盐和用作预防和治疗由异常细胞生长引起的疾病的药物组合物，其包括该化合物作为有效成分。由于这种新型的2,4,7-取代噻吩[3,2-d]嘧啶化合物表现出对参与生长因子信号传导的各种蛋白激酶具有卓越的抑制活性，因此它可用作预防或治疗由异常细胞生长引起的疾病的药剂。
• US9422307B2
  申请人：——

  公开号：US9422307B2

  公开（公告）日：2016-08-23
• [EN] 2, 4, 7 -SUBSTITUTED THIENO [3, 2 -D] PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS<br/>[FR] COMPOSÉS THIÉNO[3,2-D]PYRIMIDINES SUBSTITUÉS DANS LES POSITIONS 2, 4, 7, EN TANT QU'INHIBITEURS DE PROTÉINE KINASES
  申请人：KOREA INST SCI & TECH

  公开号：WO2011062372A2

  公开（公告）日：2011-05-26

  Disclosed are a 2,4,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,4,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.