(4R,6R)-5,5-dimethyl-2-(naphthalen-2-yl)-4,5,6,7-tetrahydro-1H-4,6-methanobenzo[d]imidazole | 1228030-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4R,6R)-5,5-dimethyl-2-(naphthalen-2-yl)-4,5,6,7-tetrahydro-1H-4,6-methanobenzo[d]imidazole
• CAS: 1228030-79-2
• 化学式: C₂₀H₂₀N₂
• 分子量: 288.392
• InChiKey: QWXRBMMKYBPSMT-CVEARBPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.92
• 重原子数：
  22.0
• 可旋转键数：
  1.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  28.68
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  萘-2-甲胺 、 (1R)-6,6-Dimethyl-3-oximinobicyclo[3.1.1]heptan-2-one 反应 1.0h， 以50%的产率得到(4R,6R)-5,5-dimethyl-2-(naphthalen-2-yl)-4,5,6,7-tetrahydro-1H-4,6-methanobenzo[d]imidazole
  参考文献：
  名称：

  One-step and solvent-free synthesis of fused terpene-pyrazines

  摘要：

  Solvent-free condensation reactions were carried out by heating terpene-monooximes with an excess of amines. Employing camphor- and nopinone-derived monooximes, two classes of terpene-fused pyrazine derivatives were synthesized. Besides being solvent-free, the described one-step procedure can be directed towards terpene-fused imidazole or pyrazine derivatives. Whereas the reaction worked well with arylmethanamines bearing a (hetero)aromatic substituent at the alpha-carbon, alkylamines afforded only imino-oximes. A possible reaction path is presented.

  DOI：

  10.3998/ark.5550190.0011.226