11β,17,21-trihydroxy-9-methyl-pregn-4-ene-3,20-dione | 58809-71-5

• 英文名称: 11β,17,21-trihydroxy-9-methyl-pregn-4-ene-3,20-dione
• 英文别名: 11β,17,21-Trihydroxy-9-methyl-pregn-4-en-3,20-dion；(8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-9,10,13-trimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
• CAS: 58809-71-5
• 化学式: C₂₂H₃₂O₅
• 分子量: 376.493
• InChiKey: PBHSSBQKAGRVAZ-OAUGPMCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (20Ξ)-11β-hydroxy-9-methyl-17,20;20,21-bis-methylenedioxy-pregn-4-en-3-one 在 溶剂黄146 作用下， 生成 11β,17,21-trihydroxy-9-methyl-pregn-4-ene-3,20-dione
  参考文献：
  名称：

  BISMETHYLENEDIOXY STEROIDS. II. SYNTHESIS OF 9α-METHYLHYDROCORTISONE AND 9α-METHYLPREDNISOLONE¹

  摘要：

  DOI：

  10.1021/ja01552a079

文献信息

• 21-Hydroxylation of steroids
  申请人：SANOFI

  公开号：EP3015550A1

  公开（公告）日：2016-05-04

  Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.

  一般来说，本发明涉及类固醇羟化领域。更具体地说，本发明涉及一种在细胞中进行类固醇 21- 羟基化的方法。本发明还涉及表达类固醇 21-羟化酶或类固醇 21-羟化酶的细胞、包含编码类固醇 21-羟化酶核酸的表达载体以及用于在细胞中实施类固醇 21-羟化方法的试剂盒。
• 21-hydroxylation of steroids
  申请人：SANOFI

  公开号：US10385376B2

  公开（公告）日：2019-08-20

  Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.

  一般来说，本发明涉及类固醇羟化领域。更具体地说，本发明涉及一种在细胞中进行类固醇 21- 羟基化的方法。本发明还涉及表达类固醇 21-羟化酶或类固醇 21-羟化酶的细胞、包含编码类固醇 21-羟化酶核酸的表达载体以及用于在细胞中实施类固醇 21-羟化方法的试剂盒。
• 21-HYDROXYLATION OF STEROIDS
  申请人：SANOFI

  公开号：EP3212800A1

  公开（公告）日：2017-09-06
• 21-Hydroxylation of Steroids
  申请人：SANOFI

  公开号：US20170321241A1

  公开（公告）日：2017-11-09

  Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.
• US5667783A
  申请人：——

  公开号：US5667783A

  公开（公告）日：1997-09-16