4-(3-(1-cyclohexyl-5-methyl-1H-pyrazol-3-yl)propyl)morpholine | 1351437-94-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(3-(1-cyclohexyl-5-methyl-1H-pyrazol-3-yl)propyl)morpholine
• 英文别名: 4-[3-(1-Cyclohexyl-5-methylpyrazol-3-yl)propyl]morpholine
• CAS: 1351437-94-9
• 化学式: C₁₇H₂₉N₃O
• 分子量: 291.437
• InChiKey: SYNHIWXNFXDBQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  30.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pyrazole compounds as sigma receptor inhibitors
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2395003A1

  公开（公告）日：2011-12-14

  The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

  该发明涉及具有通式(I)的化合物，对σ受体具有药理活性，涉及制备这些化合物的方法，包括它们的药物组合物，以及它们用于治疗和/或预防涉及σ受体的疾病的用途。
• [EN] PYRAZOLE COMPOUNDS AS SIGMA RECEPTOR INHIBITORS<br/>[FR] COMPOSÉS PYRAZOLE COMME INHIBITEURS DU RÉCEPTEUR SIGMA
  申请人：ESTEVE LABOR DR

  公开号：WO2011147910A1

  公开（公告）日：2011-12-01

  The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

  这项发明涉及具有对sigma受体具有药理活性的一般式(I)化合物，涉及制备这些化合物的方法，包括它们的药物组合物，以及它们用于治疗和/或预防涉及sigma受体的疾病的用途。
• IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR
  申请人：CUBERES-ALTISENT Rosa

  公开号：US20110281848A1

  公开（公告）日：2011-11-17

  The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.

  本发明涉及式(I)的化合物，其制备方法，包含这些化合物的药物以及它们在制造用于治疗人类和动物的药物中的应用。
• SIGMA RECEPTOR INHIBITORS
  申请人：Garcia López Monica

  公开号：US20130158029A1

  公开（公告）日：2013-06-20

  The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

  本发明涉及通式(I)的化合物，其具有对sigma受体的药理活性，以及制备这些化合物的过程，包括含有它们的制药组合物，以及它们用于治疗和/或预防涉及sigma受体的疾病的用途。
• [EN] USE OF SIGMA RECEPTOR LIGANDS IN OSTEOARTHRITIS<br/>[FR] UTILISATION DE LIGANDS DES RÉCEPTEURS SIGMA DANS L'ARTHROSE
  申请人：ESTEVE LABOR DR

  公开号：WO2016096125A1

  公开（公告）日：2016-06-23

  The invention relates to compounds of formula (I) or formula (II) having pharmacological activity towards the sigma receptor, for use in the treatment or prevention of osteoarthritis and pain due to osteoarthritis.

  本发明涉及具有对sigma受体具有药理活性的式（I）或式（II）化合物，用于治疗或预防骨关节炎和由骨关节炎引起的疼痛。