1-nitro-2,3-diphenylpropane | 60947-45-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-nitro-2,3-diphenylpropane
• 英文别名: 1-nitro-2,3-diphenyl-propane；1-Nitro-2,3-diphenyl-propan；1-Nitro-2,3-diphenylpropan；2,3-Diphenyl-1-nitropropan；(3-Nitro-2-phenylpropyl)benzene
• CAS: 60947-45-7
• 化学式: C₁₅H₁₅NO₂
• 分子量: 241.29
• InChiKey: OXACAYFALCOGGG-UHFFFAOYSA-N

物化性质

• 沸点：
  360.2±31.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硝酸 作用下， 生成 1-nitro-2,3-diphenylpropane
  参考文献：
  名称：

  Konowalow; Dobrowolski, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1905, vol. 37, p. 548

  摘要：

  DOI：

文献信息

• Generation of nitroalkanes, hydroximoyl halides and nitrile oxides from the reactions of β-nitrostyrenes with Grignard or organolithium reagents
  作者：Ching-Fa Yao、Kuo-Hsi Kao、Ju-Tsung Liu、Cheng-Ming Chu、Yeh Wang、Wen-Chang Chen、Yu-Mei Lin、Wen-Wei Lin、Ming-Chung Yan、Jing-Yuan Liu、Ming-Ching Chuang、Jin-Lien Shiue

  DOI：10.1016/s0040-4020(97)10356-8

  日期：1998.1

  products 6 and/or 7 are observed if the nitronates, generated from the substrate 1a, are added to 85% aqueous H2SO4 but only the hydrolyzed carboxylic acids 9 are generated when the β-nitrostyrenes 2 are reacted with Grignard reagents and worked up under the same condition. The nitrile oxides 7 can undergo 1,3-dipolar cycloaddition with alkenes or alkynes to generate 2-isoxazolines or isoxazoles. A one-pot

  β型硝基苯乙烯1或2与格氏或有机锂试剂反应在乙醚或THF溶液由1,4-加成中间nitronates以产生甲。当用稀盐酸处理A时，获得高产率的硝基烷3（和肟4）或5。当将中间体A缓慢加入到冰冷的浓氢卤酸中时，可以分离出羟甲酰卤6、8或一氧化氮7。如果从基材1a产生的硝酸盐观察到相同的产物6和/或7。将β-硝基苯乙烯2加入到85％的H 2 SO 4水溶液中，但是当β-硝基苯乙烯2与格氏试剂反应并在相同条件下进行后处理时，仅产生水解的羧酸9。腈氧化物7可与烯烃或炔烃进行1，3-偶极环加成反应以生成2-异恶唑啉或异恶唑。据报道，通过分子内一氧化氮-烯烃环加成反应可以一锅合成[n，3,0]双环（n = 3或4）化合物23-27。
• Solvent-Free, One-Pot Conjugate Addition of Benzyl Bromides to β-Nitro­alkenes Mediated by Magnesium Powder
  作者：Jin-Xian Wang、Wei Shi

  DOI：10.1055/s-0028-1083329

  日期：2009.2

  efficient methodology for conjugate addition of benzyl bromides to β-nitrostyrenes mediated by magnesium powder in one pot under solvent-free conditions at 0 ˚C has been developed. Advantages of this method are excellent yields, short reaction times, operational simplicity, and avoidance of the use of organic solvents. β-nitrostyrenes - benzyl bromide - conjugate addition - solvent-free - magnesium

  已开发出一种方便有效的方法，用于在无溶剂条件下于0°C的条件下，将一锅中的镁粉将苄基溴共轭添加到β-硝基苯乙烯中。该方法的优点是优异的收率，较短的反应时间，操作简单以及避免使用有机溶剂。 β-硝基苯乙烯-苄基溴-共轭加成-无溶剂-镁粉
• Solvent- and Catalyst-Free Conjugate Additions of Organozinc to β-Nitroalkene
  作者：Jin-Xian Wang、Danfeng Huang

  DOI：10.1055/s-2007-985588

  日期：——

  Conjugate addition of allylzinc and benzylzinc reagents to β-nitroalkenes was carried out without solvent and catalyst at room temperature to give products in high yield.

  烯丙基锌和苄基锌试剂与β-硝基烯烃的共轭加成反应在室温下进行，无需溶剂和催化剂，可获得高收率产物。
• ?,?-Doppeldeprotonierte Nitroalkane: Super-Enamine? Vorl�ufige Mitteilung
  作者：Rainer Henning、Friedrich Lehr、Dieter Seebach

  DOI：10.1002/hlca.19760590634

  日期：——

  α,β-Doubly deprotonated nitroalkanes: Super-enamines?

  α，β-双去质子化的硝基烷：超级烯胺？
• Additions of organomanganese reagents to conjugated nitroolefins
  作者：I.N.N. Namboothiri、Alfred Hassner

  DOI：10.1016/0022-328x(96)06150-5

  日期：1996.7

  Additions of organomanganese reagents to aromatic and aliphatic conjugated nitroolefins were examined for the first time. In most cases reaction proceeded rapidly at -30 degrees C. Unlike Mn reagents lacking beta-hydrogens (Me, Ph), which lead to oxidative coupling and reductive dimerisation of nitrostyrenes, benzylmanganese chloride gives 1,4-addition in yields exceeding Grignard or Cu-assisted additions. At 0 degrees C alkyl(Bu, Pr)-manganese reagents undergo an addition-migration-elimination process with nitrostyrenes providing a convenient and stereospecific entry into arylated trans-olefins.