N-ethyldiisopropylammonium formate | 482288-57-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethyldiisopropylammonium formate
• 英文别名: diisopropylethylamine formate；Diisopropyl-ethylammonium formate；ethyl-di(propan-2-yl)azanium;formate
• CAS: 482288-57-3
• 化学式: CH₂O₂*C₈H₁₉N
• 分子量: 175.271
• InChiKey: NEMXKYUFIKIXOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  44.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] SOLVENTS<br/>[FR] SOLVANTS
  申请人：BIONIQS LTD

  公开号：WO2009034329A1

  公开（公告）日：2009-03-19

  There is described the use of a protic ionic liquid comprising a trialkylammonium salt as a solvent.

  这里描述了一种包含三烷基铵盐的质子离子液体作为溶剂的使用。
• PROCESS FOR MAKING MONTELUKAST INTERMEDIATES
  申请人：Thijs Lambertus

  公开号：US20090270628A1

  公开（公告）日：2009-10-29

  A process for making a montelukast intermediate of formula (1) is achieved by reacting a compound of formula (2): with a hydrogen source in the presence of a ruthenium catalyst of formula (9): or a dimer thereof, wherein n represents a number from 1 to 3, to form a compound of formula (1): generally in high enantiomeric purity.

  制备一种公式（1）的蒙特卢卡斯中间体的过程是通过将公式（2）的化合物与一种氢源在存在公式（9）的钌催化剂或其二聚体的情况下反应，其中n表示1到3的数字，形成公式（1）的化合物，通常具有高对映选择性纯度。
• [EN] PROCESS FOR PREPARING (4S)- OR (4R)-3,4-DIHYDROXY-2,6,6-TRIMETHYLCYCLOHEX-2-ENONE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE (4S)- OU DE (4R)-3,4-DIHYDROXY-2,6,6-TRIMÉTHYLCYCLOHEX-2-ÉNONE
  申请人：BASF SE

  公开号：WO2018114732A1

  公开（公告）日：2018-06-28

  The present invention relates to a new process for the preparation of one of the enantiomers of 3,4-dihydroxy-2,6,6-trimethylcyclohex-2-enoneand to a process for preparing (3S,3'S)-astaxanthin, which comprises the step of providing the (4S)-enantiomerof 3,4-dihydroxy-2,6,6-trimethylcyclohex-2-enone.

  本发明涉及一种制备3,4-二羟基-2,6,6-三甲基环己-2-烯酮对映体之一的新工艺，以及制备(3S,3'S)-虾青素的工艺，其中包括提供3,4-二羟基-2,6,6-三甲基环己-2-烯酮的(4S)-对映体的步骤。
• Process for producing optically active olefin
  申请人：Kuraray Co., Ltd.

  公开号：EP0566030A2

  公开（公告）日：1993-10-20

  A process for producing an optically active olefin represented by a formula wherein R1 represents an organic group and X represents a polycyclic carbon ring group, by reacting a corresponding optically active ester derivative represented by a formula wherein R1 and X are as defined above and R2 represents a hydrogen atom, an alkoxy group, an alkenyloxy group or a substituted or unsubstituted aralkyloxy group, with formic acid or a salt thereof in the presence of a catalyst comprising a palladium salt and a tertiary phosphine. Said process makes it possible to produce, at a high yield at a high selectivity, an optically active olefin which has a physiological activity and is useful as a medicine or is useful as an intermediate for the synthesis of physiologically active steroids. Further, said process uses no harmful reagent such as mercury or the like. Thus, it is advantageous as an industrial process.

  一种生产由式表示的光学活性烯烃的工艺 其中 R1 代表有机基团，X 代表多环碳环基团，通过与相应的由式表示的光学活性酯衍生物反应制得的过程 其中 R1 和 X 如上定义，R2 代表氢原子、烷氧基、烯氧基或取代或未取代的烷氧基，与甲酸或其盐在由钯盐和叔膦组成的催化剂存在下反应。 上述工艺可以高产率、高选择性地生产出具有生理活性的光学活性烯烃，该烯烃可用作药物或合成具有生理活性的类固醇的中间体。此外，上述工艺不使用汞等有害试剂。因此，它作为一种工业工艺是非常有利的。
• PRODUCTION METHOD FOR OLIGONUCLEOTIDES
  申请人：AJINOMOTO CO., INC.

  公开号：EP3925964A1

  公开（公告）日：2021-12-22

  A method for producing an oligonucleotide that can complete a condensation reaction to improve a condensation yield, and can markedly reduce impurities such as single base deletion form (N-1mer) and the like is provided. A method for producing an oligonucleotide, including a step of removing a temporary protecting group of a 5'-hydroxyl group by adding an acid to a protected oligonucleotide having a phosphorothioate (PS), phosphate (PO) or H-phosphonate moiety, and deacylating a by-product having an acylated 5'-hydroxyl group by solvolysis.

  本发明提供了一种生产寡核苷酸的方法，该方法可完成缩合反应以提高缩合率，并可显著减少单碱基缺失形式（N-1mer）等杂质。一种生产寡核苷酸的方法，包括通过向具有硫代磷酸酯（PS）、磷酸酯（PO）或 H-膦酸酯分子的受保护寡核苷酸中添加酸来去除 5'-羟基的临时保护基团，并通过溶解作用使具有酰化 5'-羟基的副产物脱乙酰基的步骤。