3,3,7,7-Tetraethyl-1,5-diazabicyclo<3.3.0>octan-2,4,6,8-tetron | 6495-34-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,3,7,7-Tetraethyl-1,5-diazabicyclo<3.3.0>octan-2,4,6,8-tetron
• 英文别名: 2,2,6,6-tetraethyl-pyrazolo[1,2-a]pyrazole-1,3,5,7-tetraone；2,2,6,6-Tetraaethyl-pyrazolo[1,2-a]pyrazol-1,3,5,7-tetraon；3,3,7,7-Tetraethyl-<1,5>diaza-bicyclo<3.3.0>octan-2,4,6,8-tetraoxid；2,2,6,6-Tetraethyl-1H,5H-pyrazolo-<1,2-a>-2H,6H-pyrazol-1,3,5,7-tetron；2,2,6,6-Tetraethyl-perhydropyrazolo<1.2-a>pyrazoltetron-(1,3,5,7)；2,2,6,6-Tetraethyl-1,3,5,7-tetraketopyrazolo<1,2-a>pyrazol；2,2,6,6-Tetraethylpyrazolo[1,2-a]pyrazole-1,3,5,7-tetrone
• CAS: 6495-34-7
• 化学式: C₁₄H₂₀N₂O₄
• 分子量: 280.324
• InChiKey: ODHDUXQBVOWBET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.25
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3,3,7,7-Tetraethyl-1,5-diazabicyclo<3.3.0>octan-2,4,6,8-tetron 、 borane 以50%的产率得到
  参考文献：
  名称：

  KEMP D. S.; CHABALA J. C.; MARSON S. A., TETRAHEDRON LETT. , 1978, NO 6, 543-546

  摘要：

  DOI：
• 作为产物：
  描述：

  二氯化二乙基丙二酰 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3,3,7,7-Tetraethyl-1,5-diazabicyclo<3.3.0>octan-2,4,6,8-tetron
  参考文献：
  名称：

  Childlessness and the Psychological Well-Being of Older Persons

  摘要：

  Objectives. Rapid growth in the size of the childless elderly population has prompted concerns about the negative effects of childlessness on psychological well-being. This study adds to this line of inquiry by examining the effects of childlessness on two important dimensions of elderly persons' psychological well-being: loneliness and depression.Methods. Using the 1993 Asset and Health Dynamics Among the Oldest Old data set, the authors estimated logistic and ordinary least squares regression models of psychological well-being for a nationally representative sample of people aged 70 and older (N = 6,517).Results. Childlessness per se did not significantly increase the prevalence of loneliness and depression at advanced ages, net of other factors. There also was no statistical evidence for the hypothesis that childlessness increases loneliness and depression for divorced, widowed, and never married elderly persons. Sex, however, altered how childlessness and marital status influenced psychological well-being. Divorced, widowed, and never married men who were childless had significantly higher rates of loneliness compared with women in comparable circumstances; divorced and widowed men who were childless also had significantly higher rates of depression than divorced and widowed women.Discussion. The Findings suggest that it is important to understand the consequences of childlessness in the context of marital status and sex.

  DOI：

  10.1093/geronb/56.5.s311

文献信息

• Neue Untersuchungen auf dem Gebiet des 1,5-Diazabicyclo[3.3.0]octan-2,4,6,8-tetrons einschließlich Kristallstrukturbestimmung der unsubstituierten Stammverbindung
  作者：Gerrit Fritsch、Gerwalt Zinner、Dietrich Mootz、Marianne Scherf、Hartmut Wunderlich

  DOI：10.1002/ardp.19863190714

  日期：——

  noch nicht beschriebenen monosubst. Vertreter der 1,5‐Diazabicyclo[3.3.0]octan‐2,4,6,8‐tetrone sowie deren unsubst. Stammverbindung 5 zugänglich. Hierfür erfolgte der Strukturbeweis neben den üblichen analytischen Methoden auch präparativ durch Reaktion an beiden aktiven (CH2)‐Gruppen und durch Bestimmung der Kristallstruktur. Das Molekül ist mit Ausnahme der H‐Atome innerhalb von 2 pm planar und besitzt

  未被取代的 3,5-吡唑烷二酮 (1) 成为了单物质。1,5-二氮杂双环 [3.3.0] 辛烷-2,4,6,8-四氢呋喃及其非物质的代表。根化合物 5 可访问。除了通常的分析方法外，还通过在两个活性 (CH2) 基团上反应和确定晶体结构来初步验证结构。除 H 原子外，分子在 2 pm 内是平面的，并且作为一个整体具有本征对称性 2 / m-C2h。键长为 N - N 141.4 (2)、N - C 139.1 (1)、C - C 150.9 (1) 和 C - O 120.1 (1) pm。