N-butyl-2,6-dideoxy-2,6-imino-D-glycero-L-altro-heptitol | 1227834-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-butyl-2,6-dideoxy-2,6-imino-D-glycero-L-altro-heptitol
• CAS: 1227834-68-5
• 化学式: C₁₁H₂₃NO₅
• 分子量: 249.307
• InChiKey: ZQVLWTTWYIVORB-SSRBZLIGSA-N

反应信息

• 作为产物：
  描述：

  3,4,5,7-tetra-O-benzyl-N-butyl-2,6-dideoxy-2,6-imino-D-glycero-L-altro-heptitol 在 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 、 水 、 溶剂黄146 为溶剂， 反应 48.0h， 以100%的产率得到N-butyl-2,6-dideoxy-2,6-imino-D-glycero-L-altro-heptitol
  参考文献：
  名称：

  Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities

  摘要：

  Several N-alkyl and hydroxyethyl-substituted iminosugar derivatives, including L-altro and D-galacto epimers, were synthesized and the effects of these synthetic iminosugars on proliferation of mouse splenocytes were evaluated in the MTT assay. The experimental data demonstrated that the N-alkylated D-galacto iminosugars showed better inhibitory activities than L-altro analogues, which might hold potential as immunosuppressive agents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.01.021