7-Methoxy-pteridin | 204443-27-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 7-Methoxy-pteridin
• 英文别名: 7-Methoxypteridine
• CAS: 204443-27-6
• 化学式: C₇H₆N₄O
• 分子量: 162.151
• InChiKey: NMUINCUJOZFODB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7(8H)-蝶啶酮 在 甲醇 、 五氯化磷 、 三氯氧磷 作用下， 生成 7-Methoxy-pteridin
  参考文献：
  名称：

  Albert et al., Journal of the Chemical Society, 1954, p. 3832,3833

  摘要：

  DOI：

文献信息

• Parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same
  申请人：Platform Brightworks Two, Ltd.

  公开号：US10028949B2

  公开（公告）日：2018-07-24

  There may be provided compositions of lipophilic pharmaceutical agents with improved solubility and stability. For example, there may be provided a non-aqueous composition that comprises a lipophilic pharmaceutical agent, and an amphiphilic polymeric solvent such as PEG400 but essentially free of organic solvents and non-solubilized particles. The composition may be further diluted with a desired aqueous diluent such as an infusion fluid for parenteral administration to a subject such as a human. The compositions may be useful for the treatment for diseases or conditions that are sensitive to lipophilic agents, such as infectious diseases, malignant or autoimmune diseases.

  可提供具有更好溶解性和稳定性的亲脂性药剂组合物。例如，可以提供一种非水性组合物，其中包括亲脂性药剂和两亲性聚合物溶剂（如 PEG400），但基本上不含有机溶剂和非增溶颗粒。该组合物可进一步用所需的水性稀释剂稀释，如输液，用于人等受试者的非肠道给药。该组合物可用于治疗对亲脂性制剂敏感的疾病或病症，如传染性疾病、恶性或自身免疫性疾病。
• Compositions and methods for organ specific delivery of nucleic acids
  申请人：The Board of Regents of the University of Texas System

  公开号：US11229609B2

  公开（公告）日：2022-01-25

  The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

  本公开提供的组合物可将核酸组合物优先靶向或递送至特定器官。在某些实施方案中，组合物包含可用于递送核酸的类固醇或甾醇、可电离阳离子脂质、磷脂、PEG 脂质和永久阳离子脂质。
• IMPROVED PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME
  申请人：Board of Regents, The University of Texas System

  公开号：EP2701684A1

  公开（公告）日：2014-03-05
• COMPOSITIONS OF SURFACE-MODIFIED THERAPEUTICALLY ACTIVE PARTICLES BY ULTRA-RAPID FREEZING
  申请人：Board of Regents, The University of Texas System

  公开号：EP3827260A1

  公开（公告）日：2021-06-02
• COMPOSITIONS AND METHODS FOR ORGAN SPECIFIC DELIVERY OF NUCLEIC ACIDS
  申请人：The Board Of Regents Of The University Of Texas System

  公开号：EP3846822A1

  公开（公告）日：2021-07-14