4-dimethylamino-phenyldiazenesulfonic acid, sodium salt | 140-56-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-dimethylamino-phenyldiazenesulfonic acid, sodium salt
• 英文别名: Fenaminosulf；Dexon；(4-dimethylamino-phenyl)-diazenesulfonic acid ; sodium-salt；(4-Dimethylamino-phenyl)-diazensulfonsaeure; Natrium-Salz；sodium;N-[4-(dimethylamino)phenyl]iminosulfamate
• CAS: 140-56-7
• 化学式: C₈H₁₀N₃O₃S*Na
• 分子量: 251.241
• InChiKey: IWDQPCIQCXRBQP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.5
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

丝核菌和甜菜有一个线粒体系统，可以在DPNH/烟酸腺嘌呤二核苷酸的 presence 下分解脱氧核糖核酸。

RHIZOCTONIA & SUGAR BEETS HAVE A MITOCHONDRIAL SYSTEM THAT DECOMP DEXON IN PRESENCE OF DPNH /NICOTINAMIDE-ADENINE DINUCLEOTIDE/.

来源:Hazardous Substances Data Bank (HSDB)

代谢

/APHANOMYCES COCHLOIDES DRECHS/ 根部提取物的无线传真显示，脱氢酶迅速转化成至少四种未知的(14)C-标记化合物。

RADIOAUTOGRAPHS OF /APHANOMYCES COCHLOIDES DRECHS/ ROOT EXTRACTS SHOWED THAT DEXON WAS RAPIDLY CONVERTED INTO AT LEAST FOUR UNIDENTIFIED (14)C-LABELED COMPOUNDS.

来源:Hazardous Substances Data Bank (HSDB)

代谢

假单胞菌属的FRAGI通过共代谢过程代谢DEXON。其中一个形成的化合物被鉴定为N，N-二甲基-p-苯二胺。该酶，一种还原酶，在可溶性组分中发现，需要二硫苏糖醇作为还原剂。当DEXON应用于土壤时，也发现了N，N-二甲基-p-苯二胺。

PSEUDOMONAS FRAGI METABOLIZES DEXON BY CO-METABOLIC PROCESS. ONE ... CMPD FORMED WAS IDENTIFIED AS N,N-DIMETHYL-P-PHENYLENEDIAMINE. THE ENZYME, A REDUCTASE, WAS FOUND IN SOLUBLE FRACTION & REQUIRED DITHIOERYTHREITOL AS REDUCTANT. WHEN DEXON WAS APPLIED TO SOIL, N,N-DIMETHYL-P-PHENYLENEDIAMINE WAS ALSO FOUND.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

致癌性分类：1）人类证据：无足够数据。2）动物证据：数据不足。对人类致癌风险的总体评估为第3组：该物质对人类致癌性无法分类。/来自表格/

Classification of carcinogenicity: 1) evidence in humans: No adequate data. 2) evidence in animals: Inadequate data. Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. /From table/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

它对鸟类有中等毒性，对大鼠有中等至高度毒性，但通常使用时对植物没有药害。

It is moderately toxic to birds, moderately to highly toxic to rats, but it is not generally phytotoxic as used.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

两个研究中矛盾的结果，其中一个实验给大鼠口服/DEXON/，提示有肝致癌性的实验报告不充分，而提示没有肝致癌性的实验持续时间太短。

CONTRADICTORY RESULTS IN 2 STUDIES IN WHICH /DEXON/ WAS GIVEN ORALLY TO RATS. EXPERIMENT SUGGESTING HEPATOCARCINOGENICITY WAS INADEQUATELY REPORTED, WHILE EXPERIMENT SUGGESTING LACK OF HEPATOCARCINOGENICITY WAS OF TOO SHORT DURATION.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

五十只雄性B6C3F1小鼠和各五十只费希尔344大鼠（雌雄各半）被饲养在含有低或高浓度呋喃氨基磺的饮食中，持续78周。低浓度饮食中呋喃氨基磺的含量分别为大鼠0.01%，雄性小鼠0.19%，雌性小鼠0.10%，而高浓度饮食中这些组的含量分别为0.05%，0.10%和0.05%。在78周周期结束后，大鼠被观察了31周，小鼠被观察了19周。没有发现任何性别或物种之间新生物发展的显著关系。然而，处理过的动物确实表现出肾乳头管细胞坏死和矿化的发生率增加。结论是，在所使用的生物鉴定条件下，呋喃氨基磺对B6C3F1小鼠或费希尔344大鼠不具有致癌性。

FIFTY MALE B6C3F1 MICE & 50 FISCHER 344 RATS OF EACH SEX WERE MAINTAINED ON DIETS CONTAINING EITHER A LOW OR HIGH LEVEL OF FENAMINOSULF FOR 78 WK. THE LOW DIETARY CONCN WERE O.01, 0.19, & 0.10% FOR RATS, MALE MICE, & FEMALE MICE, RESPECTIVELY, & THE HIGH LEVELS OF FENAMINOSULF IN THE DIETS FOR THESE GROUPS WERE 0.05, 0.10 & 0.05%, RESPECTIVELY. AFTER THE 78 WK PERIOD, RATS WERE OBSERVED FOR 31 WK & MICE FOR 19 WK. NO SIGNIFICANT RELATIONSHIP WAS FOUND BETWEEN THE DEVELOPMENT OF NEOPLASMS IN EITHER SEX OR SPECIES. HOWEVER, TREATED ANIMALS DID DISPLAY AN INCREASED INCIDENCE OF NECROSIS & MINERALIZATION OF THE TUBULAR CELLS OF THE RENAL PAPILLA. IT WAS CONCLUDED THAT FENAMINOSULF WAS NOT CARCINOGENIC IN EITHER B6C3FA MICE OR FISCHER 344 RATS UNDER THE BIOASSAY CONDITIONS USED.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

DEXON 在原核和真核测试系统中的致突变潜力已通过在测试系统中使用大肠杆菌 B 得到确认。

MUTAGENIC POTENTIAL OF DEXON IN PROKARYOTIC & EUKARYOTIC TEST SYSTEMS WAS CONFIRMED USING ESCHERICHIA COLI B IN THE TEST SYSTEMS.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

磺胺芬胺可以很容易通过皮肤吸收...

Fenaminosulf is readily absorbed through the skin ... .

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  4-dimethylamino-phenyldiazenesulfonic acid, sodium salt 、 sodium hydrogensulfite 生成 肼
  参考文献：
  名称：

  Stolle, Chemische Berichte, 1912, vol. 45, p. 2684 Anm.

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium sulfite 作用下， 生成 4-dimethylamino-phenyldiazenesulfonic acid, sodium salt
  参考文献：
  名称：

  Stolle; Gunzert, Journal fur praktische Chemie (Leipzig 1954), 1934, vol. <2>139, p. 141,143

  摘要：

  DOI：

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ag: MVol.B6, 1.16.3, page 292 - 295
  作者：

  DOI：——

  日期：——
• Stolle, R., Berichte der Deutschen Chemischen Gesellschaft, 1912, vol. 45, p. 2680 - 2685
  作者：Stolle, R.

  DOI：——

  日期：——
• Stolle; Gunzert, Journal fur praktische Chemie (Leipzig 1954), 1934, vol. <2>139, p. 141,143
  作者：Stolle、Gunzert

  DOI：——

  日期：——
• Stolle, Chemische Berichte, 1912, vol. 45, p. 2684 Anm.
  作者：Stolle

  DOI：——

  日期：——