2-(5-chlorobenzothiazol-2-ylsulfanyl)-1-[4-(1-ethyl-propyl)piperazin-1-yl]-ethanone hydrochloride | 485797-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(5-chlorobenzothiazol-2-ylsulfanyl)-1-[4-(1-ethyl-propyl)piperazin-1-yl]-ethanone hydrochloride
• 英文别名: 2-[(5-Chloro-1,3-benzothiazol-2-yl)sulfanyl]-1-(4-pentan-3-ylpiperazin-1-yl)ethanone;hydrochloride
• CAS: 485797-68-0
• 化学式: C₁₈H₂₄ClN₃OS₂*ClH
• 分子量: 434.454
• InChiKey: FJNDKRCHJPFIOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  90
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Substituted piperazines and diazepanes
  申请人：——

  公开号：US20040019039A1

  公开（公告）日：2004-01-29

  A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

  一种新型的取代哌嗪和二氮杂环庚烷类化合物，包括它们的药物组合物以及在治疗与组胺H3受体相关的疾病和紊乱中的应用。更具体地说，这些化合物对于治疗需要与组胺H3受体相互作用有益的疾病和紊乱是有用的。
• SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS
  申请人：High Point Pharmaceuticals, LLC

  公开号：EP1421071B1

  公开（公告）日：2009-11-18
• US7208497B2
  申请人：——

  公开号：US7208497B2

  公开（公告）日：2007-04-24
• [EN] SUBSTITUTED PIPERAZINES AND DIAZEPANES<br/>[FR] PIPERAZINES ET DIAZEPANES SUBSTITUES
  申请人：NOVO NORDISK AS

  公开号：WO2003004480A2

  公开（公告）日：2003-01-16

  A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.