dimethyl-[3-(8-oxa-1-thia-3-aza-dibenzo[e,h]azulene-2-ylmethoxy)-propyl]-amine | 629642-58-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噁庚英
• 英文名称: dimethyl-[3-(8-oxa-1-thia-3-aza-dibenzo[e,h]azulene-2-ylmethoxy)-propyl]-amine
• 英文别名: N,N-dimethyl-3-(13-oxa-3-thia-5-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2(6),4,7,9,11,14,16-octaen-4-ylmethoxy)propan-1-amine
• CAS: 629642-58-6
• 化学式: C₂₁H₂₂N₂O₂S
• 分子量: 366.484
• InChiKey: CZBPKQWNAFJZLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (8-oxa-1-thia-3-aza-dibenzo[e,h]azulene-2-yl)-methanol 、 N,N-二甲氨基氯丙烷盐酸盐 生成 dimethyl-[3-(8-oxa-1-thia-3-aza-dibenzo[e,h]azulene-2-ylmethoxy)-propyl]-amine
  参考文献：
  名称：

  [EN] 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
  [FR] 1-THIA-3-AZA-DIBENZOAZULENES UTILISES COMME INHIBITEURS DE PRODUCTION DU FACTEUR DE NECROSE TUMORALE, ET PRODUITS INTERMEDIAIRES POUR LEUR PREPARATION

  摘要：

  本发明涉及1-硫代-3-氮杂二苯并蓝类衍生物，其药学上可接受的盐和溶剂化合物，以及用于其制备的过程和中间体，还涉及其抗炎作用，特别是对肿瘤坏死因子-a（TNF-a）产生的抑制和对白细胞介素-1（IL-1）产生的抑制，以及其镇痛作用。

  公开号：

  WO2003099827A1

文献信息

• USE OF 1-THIA-DIBENZO E,H AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
  申请人：PLIVA-ISTRAZIVACKI INSTITUT d.o.o.

  公开号：EP1684751A1

  公开（公告）日：2006-08-02
• 1-Thia-3-aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders
  申请人：Mercep Mladen

  公开号：US20070078123A1

  公开（公告）日：2007-04-05

  The present invention relates to the use of derivatives from the group of 1-thia-3-aza-dibenzo[e,h]azulenes and of their pharmaceutically acceptable salts and solvates in a pharmaceutical formulation for the treatment and prevention of diseases, damages and disorders of the central nervous system (CNS) caused by disorders of the neurochemical equilibrium of biogenic amines or other neurotransmitters.
• [EN] USE OF 1-THIA-DIBENZO[E,H]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS<br/>[FR] UTILISATION DE 1-THIA-DIBENZO[E,H]AZULENES POUR LA PREPARATION DE COMPOSITIONS PHARMACEUTIQUES DESTINEES AU TRAITEMENT ET A LA PREVENTION DES MALADIES ET DES TROUBLES DU SYSTEME NERVEUX CENTRAL
  申请人：PLIVA ISTRAZIVACKI INST D O O

  公开号：WO2005049020A1

  公开（公告）日：2005-06-02

  The present invention relates to the use of derivatives from the group of 1-thia-3-aza­dibenzo[e,h]azulenes and of their pharmaceutically acceptable salts and solvates for the manufacture of a pharmaceutical formulation for the treatment and prevention of diseases, damages and disorders of the central nervous system (CNS) caused by disorders of the neurochemical equilibrium of biogenic amines or other neurotransmitters.
• [EN] 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF<br/>[FR] 1-THIA-3-AZA-DIBENZOAZULENES UTILISES COMME INHIBITEURS DE PRODUCTION DU FACTEUR DE NECROSE TUMORALE, ET PRODUITS INTERMEDIAIRES POUR LEUR PREPARATION
  申请人：PLIVA D D

  公开号：WO2003099827A1

  公开（公告）日：2003-12-04

  The present invention relates to derivatives of 1-thia-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-a (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及1-硫代-3-氮杂二苯并蓝类衍生物，其药学上可接受的盐和溶剂化合物，以及用于其制备的过程和中间体，还涉及其抗炎作用，特别是对肿瘤坏死因子-a（TNF-a）产生的抑制和对白细胞介素-1（IL-1）产生的抑制，以及其镇痛作用。