(S)-7,7-Difluorooctahydropyrrolo[1,2-a]pyrazine dihydrochloride | 1305712-21-3

• 物质功能分类: 化学试剂 - 有机试剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (S)-7,7-Difluorooctahydropyrrolo[1,2-a]pyrazine dihydrochloride
• 英文别名: (8aS)-7,7-difluoro-2,3,4,6,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazine;dihydrochloride
• CAS: 1305712-21-3
• 化学式: C7H14Cl2F2N2
• mdl: MFCD18380707
• 分子量: 235.1
• InChiKey: QZJJVCXSBJSFOG-ILKKLZGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.51
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• 6-HETEROARYLOXY- OR 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND METHOD OF USE
  申请人：AbbVie Inc.

  公开号：US20160355482A1

  公开（公告）日：2016-12-08

  Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R 1 , R 2 , and R 3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Na v 1.7 and/or Na v 1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
• US9969693B2
  申请人：——

  公开号：US9969693B2

  公开（公告）日：2018-05-15