7-Fluoroheptanenitrile | 334-44-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 7-Fluoroheptanenitrile
• 英文别名: 7-fluoro-heptanenitrile；7-Fluor-heptannitril；7-Fluorheptannitril；Heptanonitrile, 7-fluoro-
• CAS: 334-44-1
• 化学式: C₇H₁₂FN
• 分子量: 129.177
• InChiKey: CFSMWCPJTYADHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-Fluoroheptanenitrile 在 盐酸 作用下， 生成 7-氟庚酸
  参考文献：
  名称：

  Anodic Syntheses Involving ι-Monohalocarboxylic Acids¹

  摘要：

  DOI：

  10.1021/ja01591a062
• 作为产物：
  描述：

  7-溴庚腈 在 potassium fluoride 、 二乙二醇 作用下， 生成 7-Fluoroheptanenitrile
  参考文献：
  名称：

  Toxic Fluorine Compounds. V.¹ ι-Fluoronitriles and ι-Fluoro-ι'-nitroalkanes

  摘要：

  DOI：

  10.1021/ja01595a058

文献信息

• Approaches towards the synthesis of fluoro(cyclo)alkylamines
  作者：A.D. Windhorst、L. Bechger、G.W.M. Visser、W.P.M.B. Menge、R. Leurs、H. Timmerman、J.D.M. Herscheid

  DOI：10.1016/s0022-1139(96)03457-4

  日期：1996.9

  The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.
• Efficient S_N2 Fluorination of Primary and Secondary Alkyl Bromides by Copper(I) Fluoride Complexes
  作者：Yanpin Liu、Chaohuang Chen、Huaifeng Li、Kuo-Wei Huang、Jianwei Tan、Zhiqiang Weng

  DOI：10.1021/om4008967

  日期：2013.11.11

  Copper(I) fluoride complexes ligated by phenanthroline derivatives have been synthesized and structurally characterized by X-ray crystallography. These complexes adopt as either ionic or neutral forms in the solid state, depending on the steric bulkiness of the substituent groups on the phenanthroline ligands. These complexes react with primary and secondary alkyl bromides to produce the corresponding alkyl fluorides in modest to good yields. This new method is compatible with a variety of important functional groups such as ether, thioether, amide, nitrile, methoxyl, hydroxyl, ketone, ester, and heterocycle moieties.
• Toxic Fluorine Compounds. VI.¹ ι-Fluoroalkylamines
  作者：F. L. M. Pattison、W. C. Howell、Robert W. White

  DOI：10.1021/ja01595a059

  日期：1956.7
• Reactions of the nitrosonium ion. 11. Fluoride transfer from complex fluoride anions to carbenium ions in the nitrosative decomposition of aliphatic azides
  作者：Michael P. Doyle、JoAnn L. Whitefleet、Richard J. Bosch

  DOI：10.1021/jo01330a021

  日期：1979.8
• SMITH, KIM R.;BORLAND, JAMES E.;SAUER, JOE D.
  作者：SMITH, KIM R.、BORLAND, JAMES E.、SAUER, JOE D.

  DOI：——

  日期：——