[(S)-3-(6-quinolin-3-yl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yloxy)-pyrrolidin-1-yl]-(tetrahydro-pyran-4-yl)-methanone | 1354690-17-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: [(S)-3-(6-quinolin-3-yl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yloxy)-pyrrolidin-1-yl]-(tetrahydro-pyran-4-yl)-methanone
• 英文别名: oxan-4-yl-[(3S)-3-[(6-quinolin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)oxy]pyrrolidin-1-yl]methanone
• CAS: 1354690-17-7
• 化学式: C₂₆H₂₉N₅O₃
• 分子量: 459.548
• InChiKey: AZWDQVFVBRILGI-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  80.7
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Use of Inhibitors of the Activity or Function of PI3K
  申请人：NOVARTIS AG

  公开号：US20150342951A1

  公开（公告）日：2015-12-03

  The invention relates to new uses of PI3K inhibitors, wherein said inhibitors have an inhibitory action on the PI3K isoform delta for the treatment of immunopathology in a subject suffering from a disease or disorder selected from malaria, leishmaniasis, trypanosomiasis, toxoplasmosis and/or neurocysticercosis, via functional inhibition of TLR9 of the infected subject.

  该发明涉及PI3K抑制剂的新用途，其中所述抑制剂对PI3K同工酶δ具有抑制作用，用于治疗患有疟疾、利什曼病、锥虫病、弓形虫病和/或神经囊虫病等疾病或紊乱的受试者的免疫病理学，通过对感染受试者的TLR9的功能抑制。
• Tetrahydro-Pyrido-Pyrimidine Derivatives
  申请人：COOKE Nigel Graham

  公开号：US20140128370A1

  公开（公告）日：2014-05-08

  The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R 1 , R 2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

  本发明涉及一种公式(I)的取代四氢嘧啶-嘌呤衍生物，其中Y、R1、R2和m如描述中所定义。这种化合物适用于治疗由PI3K酶活性介导的混乱或疾病。
• TETRAHYDRO-PYRIDO-PYRIMIDINE DERIVATIVES
  申请人：Novartis AG

  公开号：EP2590974B1

  公开（公告）日：2014-05-21
• USE OF INHIBITORS OF THE ACTIVITY OR FUNCTION OF PI3K
  申请人：Novartis AG

  公开号：EP2790705B1

  公开（公告）日：2017-12-06
• Tetrahydro-Pyrido-Pyrimidine Derivatives as PI3Kdelta inhibitors
  申请人：Novartis AG

  公开号：US20190218217A1

  公开（公告）日：2019-07-18

  The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.