23,24-dinorcholic acid | 38917-20-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 23,24-dinorcholic acid
• 英文别名: 3α,7α,12α-trihydroxy-23,24-dinor-5β-cholan-22-oic acid；3α,7α,12α-Trihydroxy-23,24-dinor-5β-cholan-22-saeure；3α.7α.12α-Trihydroxy-20β_F-methyl-5β-pregnansaeure-(21)；3α,7α,12α-Trihydroxy-23,24-dinor-5β-cholansaeure-(22)；Bisnorcholic acid；(2S)-2-[(3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoic acid
• CAS: 38917-20-3
• 化学式: C₂₂H₃₆O₅
• 分子量: 380.525
• InChiKey: BBSJMECOWBMUCF-XPCRKILGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  23,24-dinorcholic acid 在 吡啶 、 盐酸 、 苯 作用下， 生成 (10S)-3t.7t.12t-triacetoxy-10r.13c-dimethyl-17c-((S)-2-hydroxy-1-methyl-2.2-diphenyl-ethyl)-(5cH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthrene
  参考文献：
  名称：

  Abbau derCholsäurezu 3,7,12-Trioxy-pregnan-20-on

  摘要：

  Der Abbau liefert aus 100克Cholsäuresowohlüberdie Dimethyl-wieüberdie二苯基-卡宾诺等 40克Nor-cholsäure，约克。10克Bis-nor-cholsäure和aus dieer ca. 1,5克三乙酰氧基-孕烷。（不干胶标签上的碱就好了，从0.5到0.8克的达芬·利弗恩就可以了。）（作者：déftesich noch etwas verbessern lassen und 0,5-0,8 g davon liefern。）

  DOI：

  10.1002/hlca.19370200102
• 作为产物：
  描述：

  去甲胆酸 在 盐酸 作用下， 生成 23,24-dinorcholic acid
  参考文献：
  名称：

  Abbau derCholsäurezu 3,7,12-Trioxy-pregnan-20-on

  摘要：

  Der Abbau liefert aus 100克Cholsäuresowohlüberdie Dimethyl-wieüberdie二苯基-卡宾诺等 40克Nor-cholsäure，约克。10克Bis-nor-cholsäure和aus dieer ca. 1,5克三乙酰氧基-孕烷。（不干胶标签上的碱就好了，从0.5到0.8克的达芬·利弗恩就可以了。）（作者：déftesich noch etwas verbessern lassen und 0,5-0,8 g davon liefern。）

  DOI：

  10.1002/hlca.19370200102

文献信息

• A convenient synthesis of dinorbile acids:
  作者：Ashok K. Batta、Subhash C. Datta、G.Stephen Tint、David S. Alberts、David L. Earnest、Gerald Salen

  DOI：10.1016/s0039-128x(99)00064-1

  日期：1999.11

  dinorbile acids (23,24-dinor-5beta-cholan-22-oic acids, pregnane-20-carboxylic acids) in fair to good yields from norbile acid nitriles in one step by oxidative hydrolysis with oxygen in the presence of potassium-t-butoxide. The method results in stepwise overall removal of two carbon atoms in bile acid side chains in two steps. Dinorbile acids corresponding to several common bile acids have been prepared

  我们报告了一种简便的方法，可通过氧化水解与一步法从nor酸腈中以合理至良好的产率合成双壬酸（23,24-dinor-5beta-cholan-22-oic酸，pregnane-20-羧酸）叔丁醇钾存在下的氧气。该方法分两步逐步除去胆汁酸侧链中的两个碳原子。已经制备了对应于几种常见胆汁酸的双丁诺酸，并通过光谱法确认了它们的结构。这种简单的合成双降nor酸的方法可能有助于其代谢研究。
• Kanemitsu, Journal of Biochemistry, 1942, vol. 35, p. 155,165, 169
  作者：Kanemitsu

  DOI：——

  日期：——
• Hydroxy-ketones of pregnane series
  申请人：ROCHE ORGANON INC

  公开号：US02263785A1

  公开（公告）日：1941-11-25
• Enhancing Adherence in Clinical Exercise Trials
  作者：Heather A. O'Neal、Steven N. Blair

  DOI：10.1080/00336297.2001.10491747

  日期：2001.8

  Despite advancements in exercise science research and the development of techniques to promote adherence, exercise adherence is often viewed pessimistically by those in the field of public health and exercise science. It is true that exercise rates in the general population have not changed appreciably over the past two or three decades, and from this perspective, there has been little improvement in exercise adherence. However, recent clinical trials have demonstrated good adherence to both the exercise intervention and measurement protocols in controlled studies. Most methods recommended to improve adherence rates can be easily incorporated into standard research practices and require minimal time, effort, or expense. By considering adherence issues during study design and implementation, investigators can substantially enhance treatment and measurement adherence.
• Hayakawa, Proceedings of the Japan Academy, 1954, vol. 30, p. 133,134
  作者：Hayakawa

  DOI：——

  日期：——