3-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol | 75232-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol
• 英文别名: 3-Phenyl-5,6,7,8-tetrahydro-[2]naphthol
• CAS: 75232-78-9
• 化学式: C₁₆H₁₆O
• 分子量: 224.302
• InChiKey: ZJUDDAIUKKWEIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.94
• 重原子数：
  17.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  diphenyliodonium triflate 、 5,6,7,8-四氢-2-萘酚 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 6.0h， 以52%的产率得到3-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol
  参考文献：
  名称：

  Copper-catalyzed selective ortho-arylations of 2-naphthol and phenol derivatives with diaryliodonium salts

  摘要：

  The selective arylations of 2-naphthol and phenol derivatives catalyzed by Cu(OTf)(2) with using diaryliodonium(III) salts have been developed. With this method, biaryls bearing hydroxyl groups can be easily accessed in moderate to good yields. Additionally, this protocol provided an alternative for the preparation of 3-arylated binaphthalene derivatives. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.100

文献信息

• A simple and convenient phenol annulation
  作者：Dale L. Boger、Michael D. Mullican

  DOI：10.1021/jo01312a044

  日期：1980.11
• BOGER D. L.; MULLICAN M. D., J. ORG. CHEM., 1980, 45, NO 24, 5002-5004
  作者：BOGER D. L.、 MULLICAN M. D.

  DOI：——

  日期：——
• Copper-catalyzed selective ortho-arylations of 2-naphthol and phenol derivatives with diaryliodonium salts
  作者：Xiaofei Qian、Jianwei Han、Limin Wang

  DOI：10.1016/j.tetlet.2015.12.100

  日期：2016.2

  The selective arylations of 2-naphthol and phenol derivatives catalyzed by Cu(OTf)(2) with using diaryliodonium(III) salts have been developed. With this method, biaryls bearing hydroxyl groups can be easily accessed in moderate to good yields. Additionally, this protocol provided an alternative for the preparation of 3-arylated binaphthalene derivatives. (C) 2015 Elsevier Ltd. All rights reserved.