2-methyl-4,6-bis-(4-N,N-dimethylaminophenyl) thiopyrylium perchlorate | 157137-84-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-methyl-4,6-bis-(4-N,N-dimethylaminophenyl) thiopyrylium perchlorate
• 英文别名: [4-[4-[4-(Dimethylamino)phenyl]-6-methylthiopyran-2-ylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium;perchlorate
• CAS: 157137-84-3
• 化学式: C₂₂H₂₅N₂S*ClO₄
• 分子量: 448.971
• InChiKey: QZVYKUUDCQPVIJ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.05
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Fluorescent stain containing pyrylium salt or its similar salt, detection method of nucleic acid by use of it, and fluorescent staining method of biological sample
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0603783A1

  公开（公告）日：1994-06-29

  A stain for a nucleic acid characterized by containing, as an effective component, a pyrylium salt compound having Y as a negative portion and a pyrylium ring or a pyrylium-similar ring, wherein the ring is comprised of X selected from O, S, Se and Te as a hetero atom and has substituents R¹, R² and R³, wherein each of R¹ and R² is independently a hydrogen atom, sulfonate group, amino group, substituted or unsubstituted aryl group, etc., R³ is -A or -L-A, L is -L¹-, -L²-L³- or -L⁴-L⁵-L⁶-, and each of L¹ to L⁶ is independently -(CH=CH)-, a divalent group derived from the substituted or unsubstituted aryl group, etc., A is a substituted or unsubstituted aryl group, etc., and Y⁻ is an anion. A method for detecting a nucleic acid which comprises the steps of reacting a sample with the stain, and then detecting, by an optical means, the double-strand nucleic acid stained with the stain in the case that the double-strand nucleic acid is contained in the sample.

  一种用于核酸的染色剂，其特征在于作为有效成分含有一种吡鎓盐化合物，该化合物以Y为负极部分，具有吡鎓环或吡鎓类似环，其中该环由选自O、S、Se和Te的X作为杂原子组成，并具有取代基R¹、R²和R³，其中R¹和R²各自独立地为氢原子、磺酸基、氨基、取代或未取代的芳基等、R³是-A或-L-A，L是-L¹-、-L²-L³-或-L⁴-L⁵-L⁶-，其中L¹至L⁶各自独立地是-(CH=CH)-、衍生自取代或未取代芳基等的二价基团，A是取代或未取代芳基等，Y-是阴离子。一种检测核酸的方法，包括以下步骤：将样品与染色剂反应，然后在样品中含有双链核酸的情况下，通过光学手段检测被染色剂染色的双链核酸。
• Pharmaceutical compositions containing pyrylium compounds, pyrylium salts and process for manufacturing a medicament containing the aforesaid compounds
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0659407A1

  公开（公告）日：1995-06-28

  The present invention provides pharmaceutical compositions containing a pyrylium compound, a thiopyrylium compound, a selenopyrylium compound or a telluropyrylium compound or a salt of any of the aforesaid compounds as active ingredient. The compounds are selectively absorbed by cancer cells or similar growths in the human or animal body and can be used to bring about distruction of the unwanted growth on irradiation with light of wavelength 600nm to 1000nm. The invention also provides a method for the treatment of the human or animal body which comprises administering the compound to a human or animal and irradiating a locus in said animal where the compound is absorbed in order to kill cells at that locus. It further comprises the use of the aforesaid compound for the making of a medicament for use in the treatment of cancer in humans and animals.

  本发明提供了含有吡镱化合物、硫吡镱化合物、硒吡镱化合物或碲吡镱化合物或上述任一化合物的盐作为活性成分的药物组合物。这些化合物可被人或动物体内的癌细胞或类似的生长物选择性吸收，在波长为 600nm 至 1000nm 的光照射下，可用于破坏不需要的生长物。 本发明还提供了一种治疗人体或动物体的方法，该方法包括给人或动物施用该化合物，并照射动物体内吸收该化合物的部位，以杀死该部位的细胞。该方法还包括使用上述化合物制造用于治疗人类和动物癌症的药物。
• A method for detecting a target substance in a sample, utilizing pyrylium compound
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0684239B1

  公开（公告）日：2003-12-10
• Fluorescent stain containing pyrylium salt or its similar salt, detection method of nucleic acid by use of it
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0603783B1

  公开（公告）日：2001-09-26
• Determination of nucleic acid by PCR, measurement of number of microbial cells, genes, or gene-copies by PCR, and measuring-kit employed for the same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0643140B1

  公开（公告）日：2001-10-31