N-chloroacetyl-3-ethyl-2,6-bis(p-chlorophenyl)piperidin-4-one | 1017803-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-chloroacetyl-3-ethyl-2,6-bis(p-chlorophenyl)piperidin-4-one
• 英文别名: 1-(2-Chloroacetyl)-2,6-bis(4-chlorophenyl)-3-ethyl-piperidin-4-one；1-(2-chloroacetyl)-2,6-bis(4-chlorophenyl)-3-ethylpiperidin-4-one
• CAS: 1017803-12-1
• 化学式: C₂₁H₂₀Cl₃NO₂
• 分子量: 424.754
• InChiKey: NBOZASNOGSEHMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-bis(4-chlorophenyl)-3-ethylpiperidin-4-one 、 氯乙酰氯 在 三乙胺 作用下， 以 苯 为溶剂， 以80%的产率得到N-chloroacetyl-3-ethyl-2,6-bis(p-chlorophenyl)piperidin-4-one
  参考文献：
  名称：

  Synthesis and antimicrobial activities of N-chloroacetyl-2,6-diarylpiperidin-4-ones

  摘要：

  An array of new N-chloroacetyl-2,6-diarylpiperidin-4-ones has been synthesised and their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Salmonella typhi, and antifungal activity against Cryptococcus neoformans, Candida albicans, Rhizopus sp., Aspergillus flavus, and Aspergillus niger examined. Compounds 14 against P. aeruginosa, 15 against S. typhi, 16 against S. aureus, and 19 against B. subtilis showed marked antibacterial activity. Similarly, compounds 15 and 19 against A. niger and 19 against A. flavus exerted significant antifungal activities.

  DOI：

  10.1007/s00044-007-9023-x

文献信息

• Synthesis and antimicrobial activities of N-chloroacetyl-2,6-diarylpiperidin-4-ones
  作者：G. Aridoss、S. Balasubramanian、P. Parthiban、R. Ramachandran、S. Kabilan

  DOI：10.1007/s00044-007-9023-x

  日期：2007.9

  An array of new N-chloroacetyl-2,6-diarylpiperidin-4-ones has been synthesised and their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Salmonella typhi, and antifungal activity against Cryptococcus neoformans, Candida albicans, Rhizopus sp., Aspergillus flavus, and Aspergillus niger examined. Compounds 14 against P. aeruginosa, 15 against S. typhi, 16 against S. aureus, and 19 against B. subtilis showed marked antibacterial activity. Similarly, compounds 15 and 19 against A. niger and 19 against A. flavus exerted significant antifungal activities.