| 25899-70-1

• 物质功能分类: 医药中间体
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• CAS: 25899-70-1
• 化学式: C10H13N4NaO9P
• 分子量: 387.2
• InChiKey: BVSZWZWLTCBVKU-GWTDSMLYSA-N

物化性质

• 熔点：
  >116°C (dec.)
• 溶解度：
  可溶于水

计算性质

• 辛醇/水分配系数(LogP)：
  -3.24
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  193
• 氢给体数：
  6
• 氢受体数：
  10

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

生物活性

Xanthosine 5'-monophosphate sodium salt (5'-Xanthylic acid sodium salt) 是一种嘌呤代谢的中间体。Xanthosine 5'-monophosphate sodium salt 可用于遗传密码，核酸结构以及 DNA，RNA 和蛋白质合成的研究。

体外研究

Microbiological production of Xanthosine 5'-monophosphate sodium salt (XMP) in high yields opens the way for its use in foods as a flavoring agent and as a chemical intermediate for production of purine antimetabolites. Xanthosine 5'-monophosphate sodium salt also should prove valuable in the production of synthetic polynucleotides for studies on the genetic code, protein synthesis, and nucleic acid structure.

文献信息

• MULTILAYER PHARMACEUTICAL OR NUTRACEUTICAL SOLID DOSAGE FORMS COMPRISING PYRIMIDINE AND/OR PURINE DERIVATIVES AND B VITAMINS, PREPARATION AND USES THEREOF
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：US20220160744A1

  公开（公告）日：2022-05-26

  The present invention relates to a multilayer pharmaceutical or nutraceutical solid dosage form comprising at least one pyrimidine derivative, purine derivative or any salt or solvate thereof and least one B-group vitamin. It also provides three methods for producing said multilayer pharmaceutical or nutraceutical solid dosage forms. Furthermore, the present invention is also related to therapeutic uses of said multilayer pharmaceutical or nutraceutical solid dosage forms, particularly for the treatment and/or prevention of peripheral neuropathy.
• [EN] MULTILAYER PHARMACEUTICAL OR NUTRACEUTICAL SOLID DOSAGE FORMS COMPRISING PYRIMIDINE AND/OR PURINE DERIVATIVES AND B VITAMINS, PREPARATION AND USES THEREOF<br/>[FR] FORMES POSOLOGIQUES SOLIDES PHARMACEUTIQUES OU NUTRACEUTIQUES MULTICOUCHES COMPRENANT DES DÉRIVÉS DE PYRIMIDINE ET/OU DE PURINE ET DES VITAMINES B, LEUR PRÉPARATION ET LEURS UTILISATIONS
  申请人：FERRER INT

  公开号：WO2020224795A1

  公开（公告）日：2020-11-12

  The present invention relates to a multilayer pharmaceutical or nutraceutical solid dosage form comprising at least one pyrimidine derivative, purine derivative or any salt or solvate thereof and least one B-group vitamin. It also provides three methods for producing said multilayer pharmaceutical or nutraceutical solid dosage forms. Furthermore, the present invention is also related to therapeutic uses of said multilayer pharmaceutical or nutraceutical solid dosage forms, particularly for the treatment and/or prevention of peripheral neuropathy.