1,4-diacetoxy-2-acetylamino-naphthalene | 6300-60-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,4-diacetoxy-2-acetylamino-naphthalene
• 英文别名: N-(1.4-Diacetoxy-naphthyl-(2))-acetamid；1,4-Diacetoxy-2-acetylamino-naphthalin；2-Acetamino-1.4-diacetoxy-naphthalin；2-(Acetylamino)naphthalene-1,4-diyl diacetate；(3-acetamido-4-acetyloxynaphthalen-1-yl) acetate
• CAS: 6300-60-3
• 化学式: C₁₆H₁₅NO₅
• 分子量: 301.299
• InChiKey: PTXJPKFIQMFSAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-1,4-萘醌 生成 1,4-diacetoxy-2-acetylamino-naphthalene
  参考文献：
  名称：

  The Action of Diazomethane Derivatives and of Azides on Alpha and Beta Naphthoquinones

  摘要：

  DOI：

  10.1021/ja01311a029

文献信息

• N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION
  申请人：Aktas Bertal Huseyin

  公开号：US20120115915A1

  公开（公告）日：2012-05-10

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

  本文提供了抑制翻译起始的组合物和方法。描述了使用N，N'-二芳基脲和/或N，N'-二芳基硫脲化合物治疗（1）细胞增生性疾病，（2）非增生性退行性疾病，（3）病毒感染和/或（4）与病毒感染相关的疾病的组合物、方法和试剂盒。
• Kehrmann, Chemische Berichte, 1894, vol. 27, p. 3343
  作者：Kehrmann

  DOI：——

  日期：——
• N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation
  申请人：President and Fellows of Harvard College

  公开号：US20160318857A1

  公开（公告）日：2016-11-03

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.
• US9421211B2
  申请人：——

  公开号：US9421211B2

  公开（公告）日：2016-08-23
• US9932300B2
  申请人：——

  公开号：US9932300B2

  公开（公告）日：2018-04-03