2,6-bis(4-chlorophenyl)-1-methylpiperidin-4-thiosemicarbazone | 861882-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,6-bis(4-chlorophenyl)-1-methylpiperidin-4-thiosemicarbazone
• 英文别名: [[2,6-Bis(4-chlorophenyl)-1-methylpiperidin-4-ylidene]amino]thiourea
• CAS: 861882-16-8
• 化学式: C₁₉H₂₀Cl₂N₄S
• 分子量: 407.367
• InChiKey: IJPRUHIQICIWRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  85.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-bis(4-chlorophenyl)-1-methylpiperidin-4-thiosemicarbazone 在 双氧水 作用下， 以 氯仿 为溶剂， 反应 3.0h， 以82%的产率得到8-methyl-7,9-bis(4-chlorophenyl)-1,2,4,8-tetraazaspiro[4.5]decan-3-thione
  参考文献：
  名称：

  Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones

  摘要：

  Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.02.001
• 作为产物：
  描述：

  2,6-Bis(4-chlorophenyl)piperidin-4-one 在 氢气 、 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 2,6-bis(4-chlorophenyl)-1-methylpiperidin-4-thiosemicarbazone
  参考文献：
  名称：

  Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones

  摘要：

  Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.02.001

文献信息

• Synthesis of Some 2-Thioxo-imidazolidin-4-one Derivatives and its Antimicrobial Activity
  作者：A. Jamal Abdul Nasser、A. Idhayadhulla、R. Surendra Kumar、J. Selvin

  DOI：10.1155/2010/292461

  日期：——

  Series of newly prepared 3-[2,6-bis(4-substituted phenyl)-1- methylpiperidin-4- ylidene] amino}- 2-thioxo-imidazolidin-4-one derivatives (3a-3f) have been synthesized by the cyclization of compound (2a-2f), ethyl chloro acetate and fused sodium acetate. The chemical structures were confirmed by IR,¹H NMR and elemental analysis. The synthesized compounds were screened for their antimicrobial activity against four antibacterial and four antifungal organisms.

  一系列新制备的3-[2,6-双(4-取代苯基)-1-甲基哌啶-4-基]氨基}-2-硫代咪唑啉-4-酮衍生物（3a-3f），通过化合物（2a-2f），氯乙酸乙酯和熔融的乙酸钠环化合成。其化学结构经过红外光谱、核磁共振和元素分析得到确认。合成的化合物被筛选其抗菌活性，包括对四种抗菌和四种抗真菌生物的活性。
• Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones
  作者：S. Balasubramanian、C. Ramalingan、G. Aridoss、S. Kabilan

  DOI：10.1016/j.ejmech.2005.02.001

  日期：2005.7

  Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus. (c) 2005 Elsevier SAS. All rights reserved.