1-Methyl-2,6-bis-(p-chlorphenyl)-piperidon-4 | 3518-84-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Methyl-2,6-bis-(p-chlorphenyl)-piperidon-4
• 英文别名: 2.6-Bis-<4-chlor-phenyl>-1-methyl-4-oxo-piperidin；2,6-bis-(4-chloro-phenyl)-1-methyl-piperidin-4-one；2,6-Bis(4-chlorophenyl)-1-methyl-4-piperidinone；2,6-bis(4-chlorophenyl)-1-methylpiperidin-4-one
• CAS: 3518-84-1
• 化学式: C₁₈H₁₇Cl₂NO
• 分子量: 334.245
• InChiKey: WGCXGMZYGTYXDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Methyl-2,6-bis-(p-chlorphenyl)-piperidon-4 在 盐酸羟胺 、 sodium acetate trihydrate 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 2,6-bis(4-chlorophenyl)-1-methylpiperidin-4-one O-(2-(2-(4-methoxybenzylidene)hydrazinyl)thiazol-4-yl)oxime
  参考文献：
  名称：

  噻唑基取代哌啶酮肟的合成：抗氧化和抗微生物活性分析

  摘要：

  描述了新型噻唑基哌啶酮肟的合成及其抗氧化和抗菌活性的筛选。获得的结果表明，哌啶酮骨架两侧苯环 C-4 末端的活性取代基以及 2-肼基噻唑的电子效应在抗氧化和抗菌活性的发展中起主要作用。抗氧化活性似乎也基于噻唑环的自由基消散能力。噻唑中硫的亲核特性和哌啶酮骨架的亲脂性极大地影响了观察到的噻唑基哌啶酮肟的抗菌活性。在合成的化合物中, 2,

  DOI：

  10.1134/s1068162017020042
• 作为产物：
  描述：

  4-氯苯甲醛 在 ammonium acetate 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 32.0h， 生成 1-Methyl-2,6-bis-(p-chlorphenyl)-piperidon-4
  参考文献：
  名称：

  Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones

  摘要：

  Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.02.001

文献信息

• Synthesis of Some 2-Thioxo-imidazolidin-4-one Derivatives and its Antimicrobial Activity
  作者：A. Jamal Abdul Nasser、A. Idhayadhulla、R. Surendra Kumar、J. Selvin

  DOI：10.1155/2010/292461

  日期：——

  Series of newly prepared 3-[2,6-bis(4-substituted phenyl)-1- methylpiperidin-4- ylidene] amino}- 2-thioxo-imidazolidin-4-one derivatives (3a-3f) have been synthesized by the cyclization of compound (2a-2f), ethyl chloro acetate and fused sodium acetate. The chemical structures were confirmed by IR,¹H NMR and elemental analysis. The synthesized compounds were screened for their antimicrobial activity against four antibacterial and four antifungal organisms.

  一系列新制备的3-[2,6-双(4-取代苯基)-1-甲基哌啶-4-基]氨基}-2-硫代咪唑啉-4-酮衍生物（3a-3f），通过化合物（2a-2f），氯乙酸乙酯和熔融的乙酸钠环化合成。其化学结构经过红外光谱、核磁共振和元素分析得到确认。合成的化合物被筛选其抗菌活性，包括对四种抗菌和四种抗真菌生物的活性。
• SELVARAJ, S.;MARAGATHASUNDARAM, S.;PERUMAL, S.;ARUMUGAM, N., INDIAN J. CHEM., 26,(1987) N 11, 1104-1105
  作者：SELVARAJ, S.、MARAGATHASUNDARAM, S.、PERUMAL, S.、ARUMUGAM, N.

  DOI：——

  日期：——
• Synthesis of thiazole-based substituted piperidinone oximes: Profiling of antioxidant and antimicrobial activity
  作者：Salakatte Thammaiah Harini、Honnaiah Vijay Kumar、Javarappa Rangaswamy、Nagaraja Naik

  DOI：10.1134/s1068162017020042

  日期：2017.3

  The synthesis of novel thiazole-based piperidinone oximes and screening of their antioxidant and antimicrobial activity are described. The obtained results revealed that the electronic effects of active substituents at C-4 terminals of phenyl rings on either side of piperidinone skeleton, as well as at 2-hydrazinyl thiazole, played a major role in development of antioxidant and antimicrobial activity

  描述了新型噻唑基哌啶酮肟的合成及其抗氧化和抗菌活性的筛选。获得的结果表明，哌啶酮骨架两侧苯环 C-4 末端的活性取代基以及 2-肼基噻唑的电子效应在抗氧化和抗菌活性的发展中起主要作用。抗氧化活性似乎也基于噻唑环的自由基消散能力。噻唑中硫的亲核特性和哌啶酮骨架的亲脂性极大地影响了观察到的噻唑基哌啶酮肟的抗菌活性。在合成的化合物中, 2,
• Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones
  作者：S. Balasubramanian、C. Ramalingan、G. Aridoss、S. Kabilan

  DOI：10.1016/j.ejmech.2005.02.001

  日期：2005.7

  Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus. (c) 2005 Elsevier SAS. All rights reserved.