Hex-5-en-2-amine hydrochloride | 696647-52-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Hex-5-en-2-amine hydrochloride
• 英文别名: hex-5-en-2-amine;hydrochloride
• CAS: 696647-52-6
• 化学式: C6H14ClN
• 分子量: 135.63
• InChiKey: NOJKSOUACWEQFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.72
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] DNA ALKYLATION AND CROSS-LINKING AGENTS AS COMPOUNDS AND PAYLOADS FOR TARGETED THERAPIES<br/>[FR] ALKYLATION D'ADN ET AGENTS DE RÉTICULATION COMME COMPOSÉS ET CHARGES UTILES POUR THÉRAPIES CIBLÉES
  申请人：UNIV YALE

  公开号：WO2017132459A1

  公开（公告）日：2017-08-03

  The present invention is directed to compounds related to precolibactin, pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.

  本发明涉及与precolibactin相关的化合物，基于这些化合物的药物组合物以及用于提供中间体和最终化合物的合成方法，这些化合物主要是烷基化剂和抗癌化合物。所披露的化学合成方法有助于合成多种precolibactin类似物，可用于癌症治疗。
• DNA ALKYLATION AND CROSS-LINKING AGENTS AS COMPOUNDS AND PAYLOADS FOR TARGETED THERAPIES
  申请人：YALE UNIVERSITY

  公开号：US20190031650A1

  公开（公告）日：2019-01-31

  The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.