2-(heptan-3-yl)benzofuran | 1258063-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-(heptan-3-yl)benzofuran
• CAS: 1258063-98-7
• 化学式: C₁₅H₂₀O
• 分子量: 216.323
• InChiKey: LMLHXJLECYGJBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.12
• 重原子数：
  16.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  13.14
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  苯并呋喃-2-三氟硼酸钾 、 3-溴庚烷 在 乙二醇二甲醚溴化镍 、 4,7-二苯基-1,10-菲罗啉 、 lithium hexamethyldisilazane 作用下， 以 仲丁醇 为溶剂， 反应 12.0h， 以62%的产率得到2-(heptan-3-yl)benzofuran
  参考文献：
  名称：

  Nickel-Catalyzed Cross-Coupling of Potassium Aryl- and Heteroaryltrifluoroborates with Unactivated Alkyl Halides

  摘要：

  A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp(3))-Br bonds in the presence of C(sp(2))-Br bonds was achieved.

  DOI：

  10.1021/ol102717x

文献信息

• Photocatalytic decarboxylative alkylation of electron-rich heteroarenes with alkyl N-hydroxyphthalimide esters
  作者：Han-Wei Hu、Cairong Zhang、Yu-Ming Yang、Hai-Qiang Deng、Zhen-Yu Tang

  DOI：10.1016/j.tetlet.2022.153966

  日期：2022.8

  We report a direct CH alkylation of heteroarenes via photocatalytic decarboxylative couplings. A series of primary, secondary, tertiary alkyl carboxylic acids and drug-derived N-hydroxyphthalimide esters are selectively coupled with various electron-rich heteroarenes, including furans, benzofurans and thiophenes. With advantages of mild reaction conditions, broad scopes of substrates and easy handling

  我们报告了通过光催化脱羧偶联对杂芳烃进行直接 C H 烷基化。一系列伯、仲、叔烷基羧酸和药物衍生的N-羟基邻苯二甲酰亚胺酯与各种富电子杂芳烃选择性偶联，包括呋喃、苯并呋喃和噻吩。这种转化具有反应条件温和、底物范围广、易于操作等优点，是一种有价值的有机合成方法。