3-Amino-4-cyclohexyl-1,2-butanediol | 754940-01-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Amino-4-cyclohexyl-1,2-butanediol
• 英文别名: 3-amino-4-cyclohexylbutane-1,2-diol
• CAS: 754940-01-7
• 化学式: C₁₀H₂₁NO₂
• 分子量: 187.28
• InChiKey: FGESIRRBTAWOIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Peptidylaminodiols
  申请人：ABBOTT LABORATORIES

  公开号：EP0189203A2

  公开（公告）日：1986-07-30

  The invention relates to renin inhibiting compounds of the formula: wherein R10 is A is hydrogen or an N-protecting group; w is 0 or 1; B is hydrogen, hydroxy, NH, N-alkyl, loweralkyl or arylalkyl; with the proviso that when w is 1, B is NH and when w is 0, B is hydrogen, hydroxy, loweralkyl or arylalkyl; R1is loweralkyl or lipophilic or aromatic or hydrophilic amino acid side chains; m is 1-3; n is 1-3; p is 1-3; q is 1-3; s is 1-3; t is 0-2; R2 is hydrogen or loweralkyl; R3 and R4 are independently selected from loweralkyl, lipophilic or aromatic amino acid side chains; R5 and R7 are independently selected from hydrogen or loweralkyl; and R6 is hydrogen, loweralkyl, vinyl, arylalkyl or wherein R8 is hydrogen or loweralkyl, X is O, NH or S and R9 is hydrogen, loweralkyl or alkanoyl or XR9 together can be loweralkylsulfonyl, N3 or Cl.

  本发明涉及式中的肾素抑制化合物： 其中 R10 是 A是氢或N-保护基；w是0或1；B是氢、羟基、NH、N-烷基、低级烷基或芳基烷基；但当w是1时，B是NH，当w是0时，B是氢、羟基、低级烷基或芳基烷基；R1是低级烷基或亲油性或芳香性或亲水性氨基酸侧链；m是1-3；n是1-3；p是1-3；q是1-3；s是1-3；t是0-2；R2是氢或低级烷基；R3 和 R4 独立选自低烷基、亲油或芳香族氨基酸侧链；R5 和 R7 独立选自氢或低烷基；R6 是氢、低烷基、乙烯基、芳烷基或其中 R8 是氢或低烷基，X 是 O、NH 或 S，R9 是氢、低烷基或烷酰基或 XR9 合在一起可以是低烷基磺酰基、N3 或 Cl。
• Non-peptidyl alpha-succinamidoacyl aminodiols as anti-hypertensive agents
  申请人：G.D. Searle & Co.

  公开号：EP0313847A2

  公开（公告）日：1989-05-03

  Non-peptidyl compounds characterized generally as a-succinamidoacyl aminodiols are useful as renin inhibitors for the treatment of hypertension.

  一般表征为 a-琥珀酰胺酰氨基二醇的非肽类化合物可用作治疗高血压的肾素抑制剂。
• Amino diols useful in the treatment of alzheimer's disease
  申请人：ELAN PHARMACEUTICALS, INC.

  公开号：EP1712227A1

  公开（公告）日：2006-10-18

  The present invention relates to the treatment of Alzheimer's disease and other similar diseases, and more specifically to the use of compounds that inhibit betasecretase, an enzyme that cleaves amyloid precursor protein to produce A beta peptide, a major component of the amyloid plaques found in the brains of Alzheimer's sufferers, in such methods.

  本发明涉及阿尔茨海默氏症和其他类似疾病的治疗，更具体地说，涉及在此类方法中使用抑制β分泌酶的化合物，β分泌酶是一种能裂解淀粉样前体蛋白产生Aβ肽的酶，Aβ肽是阿尔茨海默氏症患者大脑中发现的淀粉样斑块的主要成分。
• PEPTIDYLAMINODIOLS
  申请人：ABBOTT LABORATORIES

  公开号：EP0295294A1

  公开（公告）日：1988-12-21
• EP0295294A4
  申请人：——

  公开号：EP0295294A4

  公开（公告）日：1990-04-10