1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)urea | 1455031-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)urea
• 英文别名: 1-[2-Fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-(oxan-4-yl)urea
• CAS: 1455031-49-8
• 化学式: C₂₃H₂₆FN₅O₂
• 分子量: 423.49
• InChiKey: OAAQLJWOWPDBGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  88.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] RAF INHIBITOR COMPOUNDS<br/>[FR] COMPOSÉS INHIBITEURS DE RAF
  申请人：DECIPHERA PHARMACEUTICALS LLC

  公开号：WO2013134298A1

  公开（公告）日：2013-09-12

  This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

  这项发明提供了化合物的公式(I)或其药用可接受的盐；包括公式(I)化合物的药物组合物；以及使用公式(I)化合物治疗特定癌症。
• RAF INHIBITOR COMPOUNDS
  申请人：Deciphera Pharmaceuticals, LLC

  公开号：US20150105367A1

  公开（公告）日：2015-04-16

  This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

  该发明提供了式(I)的化合物或其药学上可接受的盐；包含式(I)化合物的制药组合物；以及使用式(I)化合物治疗特定癌症的方法。
• US9187474B2
  申请人：——

  公开号：US9187474B2

  公开（公告）日：2015-11-17
• [EN] NEW COMPOSITIONS, THE PREPARATION AND USE THEREOF<br/>[FR] NOUVELLES COMPOSITIONS, LEUR PRÉPARATION ET LEUR UTILISATION
  申请人：KCI LICENSING INC

  公开号：WO2013134269A2

  公开（公告）日：2013-09-12

  The present teachings provide new compositions comprising polycations and polycations, and the preparation and use of these new compositions. In one aspect, the new compositions are complex coacervates. The compositions described herein can have several desired properties, including, low interfacial tension in water, adjustable cohesive strength, antimicrobial activity, suitability for dissolution at or near physiological pH, biocompatibility, and/or biodegradability. The compositions can have the ability of promoting cell attachment, cell adhesion, cell migration, cell differentiation, and/or morphogenesis. Thus, in various embodiments, the complex coacervates can be used in water-based applications, for example, in the body.