(1r,4r)-4-(aminomethyl)-N,N-dimethylcyclohexan-1-amine | 170140-79-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1r,4r)-4-(aminomethyl)-N,N-dimethylcyclohexan-1-amine
• 英文别名: 1-aminomethyl-4-N,N-dimethyl-aminocyclohexan；1-aminomethyl-4-N,N-dimethylaminocyclohexane；trans-4-(aminomethyl)-N,N-dimethylcyclohexanamine；4-(aminomethyl)-N,N-dimethylcyclohexan-1-amine
• CAS: 170140-79-1
• 化学式: C₉H₂₀N₂
• 分子量: 156.271
• InChiKey: AQRWDLOWHDZKAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1r,4r)-4-(aminomethyl)-N,N-dimethylcyclohexan-1-amine 、 2,6-二氯苯甲酰氯 以 1,4-二氧六环 为溶剂， 以55%的产率得到2,6-dichloro-N-((1-isopropylpiperidin-4-yl)methyl)benzamide
  参考文献：
  名称：

  Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir

  摘要：

  Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for the acute treatment of influenza infections to control this virus and prevent epidemics/pandemics from developing. We have discovered fast-acting, orally bioavailable acylated 4-aminopiperidines with an effective mechanism of action targeting viral hemagglutinin (HA). Our data show that these compounds are potent entry inhibitors of influenza A viruses. We present docking studies that suggest an HA binding site for these inhibitors on H5N1. Compound 16 displayed a significant decrease of viral titer when evaluated in the infectious assays with influenza virus H1N1 (A/Puerto Rico/8/1934) or H5N1 (A/Vietnam/1203/2004) strains and the oseltamivir-resistant strain with the most common H274Y mutation. In addition, compound 16 showed significant synergistic activity with oseltamivir in vitro.

  DOI：

  10.1021/acs.jmedchem.9b01900

文献信息

• [EN] PAK INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS<br/>[FR] INHIBITEURS DE PAK POUR LE TRAITEMENT DE TROUBLES DE PROLIFÉRATION CELLULAIRE
  申请人：AFRAXIS INC

  公开号：WO2013067423A1

  公开（公告）日：2013-05-10

  Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of cell proliferative disorders and/or CNS disorders.

  本文提供PAK抑制剂和利用PAK抑制剂治疗细胞增殖性疾病和/或中枢神经系统疾病的方法。
• 1,5-NAPHTHYRIDINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME
  申请人：Onco Therapy Science, Inc.

  公开号：US20150005302A1

  公开（公告）日：2015-01-01

  The present invention directs a compound represented by formula (I).

  本发明涉及一种由式(I)所表示的化合物。
• QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME
  申请人：Matsuo Yo

  公开号：US20130217671A1

  公开（公告）日：2013-08-22

  The present invention directs a compound represented by formula (I).

  本发明涉及一种由公式(I)所代表的化合物。
• Pigment dispersing agent and pigment composition containing the same
  申请人：TOYO INK MANUFACTURING CO., LTD.

  公开号：EP1022273A1

  公开（公告）日：2000-07-26

  A colourless or only slightly coloured pigment dispersing agent which can be used to disperse pigments having various hues, and which has the general formula (1)    wherein k is from 1 to 3, 1 is from 0 to 2, R1 is an amino group, R2 is a halogen atom, an amino group, a nitro group, a hydroxyl group, an alkoxy group, a carboxyl group, a sulfonic acid group, an optionally substituted alkyl group or an optionally substituted alkenyl group, X1 is -O- or -NR3- wherein R3 is a hydrogen atom, an optionally substituted alkyl group or an optionally substituted alkenyl group, Y1 is a amino derivative and Y2 is an amino derivative, a hydroxyl group, an alkoxy group or a group    wherein X1, R2, R2 k and l are defined above.

  一种无色或仅略带颜色的颜料分散剂，可用于分散各种色调的颜料，其通式为 (1) 其中 k 为 1 至 3，1 为 0 至 2，R1 为氨基，R2 为卤素原子、氨基、硝基、羟基、烷氧基、羧基、磺酸基、任选取代的烷基或任选取代的烯基、X1 是 -O- 或 -NR3- 其中 R3 是氢原子、任选取代的烷基或任选取代的烯基， Y1 是氨基衍生物，Y2 是氨基衍生物、羟基、烷氧基或基团 其中 X1、R2、R2 k 和 l 的定义如上。
• Pigment composition containing a pigment dispersing agent
  申请人：TOYO INK MANUFACTURING CO., LTD.

  公开号：EP1022273B1

  公开（公告）日：2004-07-14