3-(3-氟-4-甲基苯基)-2-疏基喹唑啉-4(3h)-酮 | 1512-75-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 3-(3-氟-4-甲基苯基)-2-疏基喹唑啉-4(3h)-酮
• 英文名称: 4-Oxo-2-mercapto-3-<3-fluor-4-methyl-phenyl>-3,4-dihydro-chinazolin
• 英文别名: 3-(3-fluoro-4-methylphenyl)-2-mercaptoquinazolin-4(3H)-one；3-(3-fluoro-4-methylphenyl)-2-sulfanylidene-1H-quinazolin-4-one
• CAS: 1512-75-0
• 化学式: C₁₅H₁₁FN₂OS
• mdl: MFCD00125946
• 分子量: 286.33
• InChiKey: UMSZYHGSMGLATF-UHFFFAOYSA-N

物化性质

• 沸点：
  454.0±55.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  33.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

文献信息

• Combination therapy to enhance the anticancer efficacy of platinum drugs
  申请人：University of Pittsburgh-of the Commonwealth System of Higher Education

  公开号：US10478437B2

  公开（公告）日：2019-11-19

  The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.

  本发明涉及减少细胞增殖和/或促进细胞死亡的组合物和方法。本发明至少部分基于以下发现：在铂类药物耐药细胞系中，某些化合物与第二种抗增殖剂（如顺铂）一起发挥协同作用，促进细胞凋亡。因此，本发明提供了新的抗癌策略。
• COMBINATION THERAPY TO ENHANCE THE ANTICANCER EFFICACY OF PLATINUM DRUGS
  申请人：University of Pittsburgh - of the Commonwealth System of Higher Education

  公开号：US20170095478A1

  公开（公告）日：2017-04-06

  The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.