N5-propanoyl-5-amino-2,3-dihydrophthalazine-1,4-dione | 14241-42-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N5-propanoyl-5-amino-2,3-dihydrophthalazine-1,4-dione
• 英文别名: 3-Propionylamino-phthalhydrazid；N-Propionyl-luminol；5-propionylamino-2,3-dihydro-phthalazine-1,4-dione；N-(1,4-dioxo-2,3-dihydrophthalazin-5-yl)propanamide
• CAS: 14241-42-0
• 化学式: C₁₁H₁₁N₃O₃
• mdl: MFCD21366999
• 分子量: 233.227
• InChiKey: CCNQQFWZTPCOEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• BIOLUMINESCENCE IMAGING OF MYELOPEROXIDASE ACTIVITY IN VIVO, METHODS, COMPOSITIONS AND APPARATUSES THEREFOR
  申请人：Sharma Vijay

  公开号：US20110250145A1

  公开（公告）日：2011-10-13

  Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.

  公开了成像受试者中过氧化物酶活性分布的方法。这些方法包括使用生物发光底物，包括发光酰胺和波长移位的发光酰胺类似物。发光酰胺类似物可以发射比发光酰胺更长波长的生物发光过氧化物酶底物，被证明对于体内成像过氧化物酶活性是有用的。所公开的方法可用于成像炎症部位和其他与体内异常MPO活性水平相关的病理条件。还公开了发光酰胺类似物的合成方法。
• PHARMACEUTICAL GRADE PHTHALAZINEDIONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：BACH PHARMA, INC

  公开号：US20160237039A1

  公开（公告）日：2016-08-18

  The present invention comprises methods of manufacturing a highly purified, pharmaceutical grade phthalazinedione for administration to a human or animal. The manufacturing methods identify and isolate starting materials, and prepare intermediate products, which are suitable for the commercial batch process production of highly purified and high-yielding intermediate products and final phthalazinedione products.

  本发明涉及制造高纯度、制药级邻苯二酮衍生物的方法，以供人类或动物使用。制造方法通过识别和分离起始材料，并制备中间产物，适用于商业批量生产高纯度和高产率的中间产物和最终邻苯二酮衍生物产品。
• Modulation of cell fates and activities by phthalazinediones
  申请人：Henry O. Mark

  公开号：US20050288291A1

  公开（公告）日：2005-12-29

  Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survival and augment medical treatments. The phthalazinediones of the invention can modulate functions related to cell growth, differentiation, activity, or death, to correct aberrations and restore homeostasis, and can serve as adjunctive therapy in treating various disease conditions.

  作为细胞内氧化还原调节剂的酞嗪二酮类化合物可用于治疗细胞内氧化还原状态受损的各种疾病状态下的细胞。通过缓冲失常的氧化还原状态，酞嗪二酮类化合物能使细胞进行生存所必需的过程，并增强医疗效果。本发明的酞嗪二酮类化合物可以调节与细胞生长、分化、活性或死亡有关的功能，纠正畸变和恢复平衡，并可作为治疗各种疾病的辅助疗法。
• MODULATION OF CELL FATES AND ACTIVITIES BY PHTHALAZINEDIONES
  申请人：Bach Pharma, Inc

  公开号：EP1924274A1

  公开（公告）日：2008-05-28
• EP1924274A4
  申请人：——

  公开号：EP1924274A4

  公开（公告）日：2008-10-08