Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1
摘要:
The development and synthesis of potent p38 alpha MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38 alpha selective pyridopyridazin-6-one series from the p38 alpha/beta dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail. (c) 2010 Elsevier Ltd. All rights reserved.