6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride | 1370371-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride
• CAS: 1370371-91-7
• 化学式: C₁₁H₁₁NO₄*ClH
• 分子量: 257.674
• InChiKey: WAPCZNCPSRHBAR-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  C₁₁H₉NO₄ 在 盐酸 、 5%-palladium/activated carbon 、 氢气 作用下， 以 水 为溶剂， 生成 6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride
  参考文献：
  名称：

  A concise synthesis of tetrahydroisoquinoline-1-carboxylic acids using a Petasis reaction and Pomeranz–Fritsch–Bobbitt cyclization sequence

  摘要：

  A sequence of two reactions: the Petasis reaction, in which an aminoacetaldehyde acetal was used as the amine component, followed by Pomeranz-Fritsch-Bobbitt cyclization, has been shown to be a convenient and simple method for the synthesis of tetrahydroisoquinoline-1-carboxylic acids. Using this method several acids have been prepared in good to excellent yields and characterized as hydrochloride salts. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.02.005