6-hydroxy-9-(2-hydroxy-phenyl)-xanthen-3-one | 199991-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-hydroxy-9-(2-hydroxy-phenyl)-xanthen-3-one
• 英文别名: 6-Hydroxy-9-(2-hydroxy-phenyl)-xanthen-3-on；NSC9037；6-Hydroxy-9-(2-hydroxyphenyl)xanthen-3-one
• CAS: 199991-33-8
• 化学式: C₁₉H₁₂O₄
• 分子量: 304.302
• InChiKey: DTORADINSJYOQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间苯二酚 、 水杨酸甲酯 在 盐酸 、 zinc(II) chloride 作用下， 生成 6-hydroxy-9-(2-hydroxy-phenyl)-xanthen-3-one
  参考文献：
  名称：

  Sen; Sircar, Journal of the Indian Chemical Society, 1923, vol. 1, p. 158,170

  摘要：

  DOI：

文献信息

• Sen; Sinha, Journal of the American Chemical Society, 1923, vol. 45, p. 2993
  作者：Sen、Sinha

  DOI：——

  日期：——
• Novel affinity labels
  申请人：Phelps J. David

  公开号：US20070269832A1

  公开（公告）日：2007-11-22

  The invention provides novel affinity labels for Ser proteases of formula: L-A-X—NH—CH(R′)C(═O)CH 2 Cl  (I) wherein L, A, X, and R′ have any of the values defined in the specification, or salts thereof, as well as compositions comprising such compounds or salts. The composition of the amino acid side-chain (R′) along with the amino acid or amino acid sequence (peptide) of the X component of formula I, affect the target selectivity of the labeled affinity ligand. Utilization of cell permeable, enzyme selective, labeled affinity ligands, provides a precise mechanism for evaluating the current and future status of cell populations.
• IN VIVO DETECTION OF APOPTOSIS
  申请人：Johnson Gary L.

  公开号：US20090142260A1

  公开（公告）日：2009-06-04

  The invention provides methods and products, such as kits, useful for determining the apoptotic state of cells in an organism, comprising detecting the presence or abundance of at least one caspase affinity labeling agent in the cells of an animal into which at least one caspase affinity labeling agent has been introduced, wherein the presence or abundance of the caspase affinity labeling agent correlates with the apoptotic state of the cells.
• COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING
  申请人：Smrcka Alan V.

  公开号：US20090221691A1

  公开（公告）日：2009-09-03

  The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β protein subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provide.
• Compositions and Methods for Inhibiting G Protein Signaling
  申请人：University of Rochester

  公开号：US20130116313A1

  公开（公告）日：2013-05-09

  The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β protein subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provided.