tert-butyl 1-oxo-1,2-dihydrospiro(benzo[f]chromene-3,4'-piperidine)-1'-carboxylate | 1013333-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: tert-butyl 1-oxo-1,2-dihydrospiro(benzo[f]chromene-3,4'-piperidine)-1'-carboxylate
• 英文别名: 1,1-Dimethylethyl 1,2-dihydro-1-oxospiro[3H-naphtho[2,1-b]pyran-3,4a(2)-piperidine]-1a(2)-carboxylate；tert-butyl 1-oxospiro[2H-benzo[f]chromene-3,4'-piperidine]-1'-carboxylate
• CAS: 1013333-60-2
• 化学式: C₂₂H₂₅NO₄
• 分子量: 367.445
• InChiKey: YHBKMAXUQLEZNF-UHFFFAOYSA-N

物化性质

• 沸点：
  536.1±50.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-乙酰基-2-萘酚 、 N-叔丁氧羰基-4-哌啶酮 在 四氢吡咯 作用下， 反应 0.15h， 以90%的产率得到tert-butyl 1-oxo-1,2-dihydrospiro(benzo[f]chromene-3,4'-piperidine)-1'-carboxylate
  参考文献：
  名称：

  Green synthesis of new naphthospiro chromanone scaffolds and their antimicrobial activity

  摘要：

  An efficient synthesis of new naphthospiro chromanone scaffolds using ionic liquids as a green solvent under microwave irradiation is presented. The reaction was also studied under conventional elevated temperature conditions. The structures of newly synthesized compounds have been elucidated by means of IR, H-1 NMR, C-13 NMR, and mass spectrometry data. All compounds were screened for their antimicrobial activity.

  DOI：

  10.1134/s1070363214080301

文献信息

• Green synthesis of new naphthospiro chromanone scaffolds and their antimicrobial activity
  作者：M. Sarasija、K. Sudershan、D. Ashok、Shivaraj

  DOI：10.1134/s1070363214080301

  日期：2014.8

  An efficient synthesis of new naphthospiro chromanone scaffolds using ionic liquids as a green solvent under microwave irradiation is presented. The reaction was also studied under conventional elevated temperature conditions. The structures of newly synthesized compounds have been elucidated by means of IR, H-1 NMR, C-13 NMR, and mass spectrometry data. All compounds were screened for their antimicrobial activity.