N,N-Dipropylimidoformamide | 48044-20-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-Dipropylimidoformamide
• 英文别名: N,N-dipropylmethanimidamide
• CAS: 48044-20-8
• 化学式: C₇H₁₆N₂
• 分子量: 128.22
• InChiKey: BLDHGACEPAYSQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  27.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Process for preparation of cyclic prodrugs of PMEA and PMPA
  申请人：——

  公开号：US20030225277A1

  公开（公告）日：2003-12-04

  The method of preparing compounds of Formula I is described: 1 wherein: M and V are cis to one another and MPO 3 H 2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, and (R)-9-(2-phosphonylmethoxypropyl)adenine; wherein V is phenyl, optionally substituted with 1-2 substituents selected from a group consisting of fluoro, chloro, and bromo; comprising: coupling a chiral 1-phenylpropane-1,3-diol, wherein the phenyl may be optionally substituted, with MPOCl 2 or an N-6 substituted analogue thereof. Additionally, methods and salt forms are described that enable isolation and purification of the desired isomer.

  描述了制备化合物I的方法：其中：M和V相互顺式，MPO3H2是从9-(2-磷酸甲氧基乙基)腺嘌呤和(R)-9-(2-磷酸甲氧基丙基)腺嘌呤组成的磷酸；其中V是苯基，可选地取代1-2个从氟、氯和溴组成的取代基；包括：将手性1-苯基丙烷-1,3-二醇（其中苯基可选地取代）与MPOCl2或其N-6取代类似物偶联。此外，还描述了使所需异构体隔离和纯化的方法和盐形式。
• An amide compound and its production and use
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0394043A1

  公开（公告）日：1990-10-24

  A range of novel amide compounds represented by the formula wherein A is a group represented by the formula and the ring B is a benzene, pyridine or cyclohexane ring, are defined and their production and insecticidal and/or acaricidal properties are described.

  一系列新型酰胺化合物，由式表示 式中 A 是由式 和环 B 是苯、吡啶或环己烷环的定义，并描述了它们的生产和杀虫及/或杀螨性。
• PROCESS FOR PREPARATION OF CYCLIC PRODRUGS OF PMEA AND PMPA
  申请人：Metabasis Therapeutics, Inc.

  公开号：EP1504014B1

  公开（公告）日：2015-12-02
• EP1504014A4
  申请人：——

  公开号：EP1504014A4

  公开（公告）日：2006-06-07
• CANNABINOID RECEPTOR MEDIATING COMPOUNDS
  申请人：The U.S.A. as represented by the Secretary, Department of Health and Human Services

  公开号：EP2919779B1

  公开（公告）日：2021-01-06