4-chloro-7-fluoro-6-methoxy-2-methylquinazoline | 1444348-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-chloro-7-fluoro-6-methoxy-2-methylquinazoline
• CAS: 1444348-44-0
• 化学式: C₁₀H₈ClFN₂O
• 分子量: 226.638
• InChiKey: QTHVVJIFDGSVDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL BENZYLAMINO SUBSTITUTED QUINAZOLINES AND DERIVATIVES AS SOS1 INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20210177851A1

  公开（公告）日：2021-06-17

  The present invention encompasses compounds of formula (I) wherein the groups R 1 to R 7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.