9-methoxy-2-((octahydroquinolin-1(2H)-yl)methyl)thiazolo[5,4-c]isoquinolin-5(4H)-one | 1201811-29-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 9-methoxy-2-((octahydroquinolin-1(2H)-yl)methyl)thiazolo[5,4-c]isoquinolin-5(4H)-one
• 英文别名: 2-(3,4,4a,5,6,7,8,8a-octahydro-2H-quinolin-1-ylmethyl)-9-methoxy-4H-[1,3]thiazolo[5,4-c]isoquinolin-5-one
• CAS: 1201811-29-1
• 化学式: C₂₁H₂₅N₃O₂S
• 分子量: 383.514
• InChiKey: DLTKLLPLCKVYPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  82.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• THIAZOLYL-AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM
  申请人：PELLICCIARI Roberto

  公开号：US20090318442A1

  公开（公告）日：2009-12-24

  The present invention relates to substituted thiazolyl- and oxazoyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及替代噻唑基和噁唑基异喹啉酮，例如作为多聚腺苷二磷酸核糖聚合酶（PARP）的调节剂。本发明还涉及替代噻唑基和噁唑基异喹啉酮的制备方法以及它们在治疗各种疾病和紊乱中的应用。
• Thiazolyl- and Oxazolyl-Isoquinolinones and Methods for Using Them
  申请人：Pellicciari Roberto

  公开号：US20130059843A1

  公开（公告）日：2013-03-07

  The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及替代噻唑基和氧唑基异喹啉酮，例如作为多聚(ADP核糖)聚合酶（PARP）调节剂。本发明还涉及制备替代噻唑基和氧唑基异喹啉酮的方法，以及它们在治疗各种疾病和障碍中的应用。
• Thiazolyl- And Oxazolyl-Isoquinolinones And Methods For Using Them
  申请人：Pellicciari Roberto

  公开号：US20150133443A1

  公开（公告）日：2015-05-14

  The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及取代噻唑基和噁唑基异喹啉酮，例如作为聚(ADP-核糖)聚合酶(PARP)调节剂的化合物。本发明还涉及制备取代噻唑基和噁唑基异喹啉酮的方法，以及它们在治疗各种疾病和疾病中的应用。
• THIAZOLYL- AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM
  申请人：Wyeth LLC

  公开号：EP2303895A1

  公开（公告）日：2011-04-06
• US8299090B2
  申请人：——

  公开号：US8299090B2

  公开（公告）日：2012-10-30