flurandrenolide acetate | 25541-02-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: flurandrenolide acetate
• 英文别名: [(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-11-yl] acetate
• CAS: 25541-02-0
• 化学式: C₂₆H₃₅FO₇
• 分子量: 478.558
• InChiKey: OVCQCQOZLZVVLA-XTLNBZDDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  99.1
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• TRANSFERRIN VARIANTS AND CONJUGATES
  申请人：Novozymes Biopharma DK A/S

  公开号：EP2201036A1

  公开（公告）日：2010-06-30
• INJECTABLE SUSTAINED-RELEASE FORMULATIONS FOR TREATMENT OF JOINT PAIN AND INFLAMMATION
  申请人：FORDOZ Pharma Corp.

  公开号：US20220096498A1

  公开（公告）日：2022-03-31

  Drug-loaded microspheres containing both a steroidal anti-inflammatory drug and a non-steroidal anti-inflammatory drug and injectable formulations containing the microspheres for sustained release of both drugs are disclosed. Methods of making such drug-loaded microspheres, formulations, and use of them for treating pains and inflammations, especially those caused by rheumatoid arthritis or osteoarthritis using such microspheres and formulations are also described.
• US4255331A
  申请人：——

  公开号：US4255331A

  公开（公告）日：1981-03-10
• [EN] TRANSFERRIN VARIANTS AND CONJUGATES<br/>[FR] VARIANTS DE TRANSFERRINE ET CONJUGUÉS
  申请人：NOVOZYMES AS

  公开号：WO2009019314A1

  公开（公告）日：2009-02-12

  Based on the three-dimensional structure of transferrin, the inventors have designed variant polypeptides (muteins) which have one or more Cysteine residues with a free thiol group (hereinafter referred to as thiotransferrin ). The variant polypeptide may be conjugated through the sulphur atom of the Cysteine residue to a bioactive compound.
• [EN] INJECTABLE SUSTAINED-RELEASE FORMULATIONS FOR TREATMENT OF JOINT PAIN AND INFLAMMATION<br/>[FR] FORMULATIONS INJECTABLES À LIBÉRATION PROLONGÉE POUR LE TRAITEMENT DES DOULEURS ET INFLAMMATIONS ARTICULAIRES
  申请人：FORDOZ PHARMA CORP

  公开号：WO2020227353A1

  公开（公告）日：2020-11-12

  Drug-loaded microspheres containing both a steroidal anti-inflammatory drug and a non-steroidal anti- inflammatory dmg and injectable formulations containing the microspheres for sustained release of both drugs are disclosed. Methods of making such drug-loaded microspheres, formulations, and use of them for treating pains and inflammations, especially those caused by rheumatoid arthritis or osteoarthritis using such microspheres and formulations are also described.