NSC11668 | 109558-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: NSC11668
• 英文别名: N⁴,N⁶-bis-(3-chloro-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diyldiamine；N⁴,N⁶-Bis-(3-chlor-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4,6-diyldiamin；4-N,6-N-bis(3-chlorophenyl)-1-methylpyrazolo[3,4-d]pyrimidine-4,6-diamine
• CAS: 109558-97-6
• 化学式: C₁₈H₁₄Cl₂N₆
• 分子量: 385.255
• InChiKey: HRCYEQFRHAXCRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  67.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHOD OF INHIBITING ABCG2 AND RELATED TREATMENTS
  申请人：Henrich Curtis J.

  公开号：US20100267652A1

  公开（公告）日：2010-10-21

  Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.
• US9114102B2
  申请人：——

  公开号：US9114102B2

  公开（公告）日：2015-08-25
• US9937217B2
  申请人：——

  公开号：US9937217B2

  公开（公告）日：2018-04-10
• [EN] METHOD OF INHIBITING ABCG2 AND RELATED TREATMENTS<br/>[FR] PROCÉDÉ D'INHIBITION DE L'ABCG2 ET TRAITEMENTS ASSOCIÉS
  申请人：US HEALTH

  公开号：WO2009061770A2

  公开（公告）日：2009-05-14

  Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.