7-Methoxy-8-nitro-1-tetralone | 99843-54-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-Methoxy-8-nitro-1-tetralone
• 英文别名: 7-Methoxy-8-nitro-tetralon-(1)；7-methoxy-8-nitro-3,4-dihydro-2H-naphthalen-1-one
• CAS: 99843-54-6
• 化学式: C₁₁H₁₁NO₄
• 分子量: 221.213
• InChiKey: HNPYADCJNVEEMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-甲氧基-1-萘满酮 在 乙酸酐 作用下， 以 乙醚 为溶剂， 以20%的产率得到7-Methoxy-6-nitro-1-tetralone
  参考文献：
  名称：

  Conformationally constrained analogues of N′-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists

  摘要：

  A series of bicyclic analogues having indan and tetrahydronaphthalene templates in the A-region were designed as conformationally constrained analogues of our previously reported potent TRPV1 antagonists (1, 3). The activities for rat TRPV1 of the conformationally restricted analogues were moderately or markedly diminished, particularly in the case of the tetrahydronaphthalene analogues. The analysis indicated that steric constraints at the benzylic position in the bicyclic analogues may be an important factor for their unfavorable interaction with the receptor. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.02.026

文献信息

• [EN] INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION<br/>[FR] INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009062285A1

  公开（公告）日：2009-05-22

  Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.

  式(I)的化合物：其中R4、R6和R7如本文所定义，可用作HIV复制的抑制剂。
• INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：Gilead Sciences, Inc.

  公开号：US20130197231A1

  公开（公告）日：2013-08-01

  Compounds of formula I: wherein R 4 , R 6 and R 7 are defined herein, are useful as inhibitors of HIV replication.

  式I的化合物： 其中R4、R6和R7在此被定义，可用作HIV复制的抑制剂。
• Inhibitors of human immunodeficiency virus replication
  申请人：GILEAD SCIENCES, INC.

  公开号：EP2757096A1

  公开（公告）日：2014-07-23

  Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.

  式 I 的化合物： 其中 R4、R6 和 R7 在本文中定义，可用作 HIV 复制的抑制剂。
• US8354429B2
  申请人：——

  公开号：US8354429B2

  公开（公告）日：2013-01-15
• Conformationally constrained analogues of N′-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists
  作者：Ju-Ok Lim、Mi-Kyoung Jin、HyungChul Ryu、Dong Wook Kang、Jeewoo Lee、Larry V. Pearce、Richard Tran、Attila Toth、Peter M. Blumberg

  DOI：10.1016/j.ejmech.2008.02.026

  日期：2009.1

  A series of bicyclic analogues having indan and tetrahydronaphthalene templates in the A-region were designed as conformationally constrained analogues of our previously reported potent TRPV1 antagonists (1, 3). The activities for rat TRPV1 of the conformationally restricted analogues were moderately or markedly diminished, particularly in the case of the tetrahydronaphthalene analogues. The analysis indicated that steric constraints at the benzylic position in the bicyclic analogues may be an important factor for their unfavorable interaction with the receptor. (C) 2008 Elsevier Masson SAS. All rights reserved.