3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol | 866529-02-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol
• 英文别名: (2R,3R,4S,5S,6R)-2-[[(9R,10S,13R,14R,17R)-17-[(2R,5S)-5,6-dimethylheptan-2-yl]-4,10,13-trimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 866529-02-4
• 化学式: C₃₅H₆₀O₆
• 分子量: 576.858
• InChiKey: UXBAUUVEYYMRCL-QPEZSDMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol 在 盐酸 、 甲醇 作用下， 反应 6.0h， 生成 4-methylergost-7-en-3-ol
  参考文献：
  名称：

  EP1927361

  摘要：

  公开号：

文献信息

• GLYCOSIDE HAVING 4-METHYLERGOST-7-EN-3-OL SKELETON AND DRUG FOR AMELIORATING HYPERGLYCEMIA
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1731527A1

  公开（公告）日：2006-12-13

  3-O-β-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.

  3-O-β-D-吡喃葡萄糖基-4-甲基麦角甾-7-烯-3-醇或含有 0.001%（质量）或更多上述化合物的组合物，是含有该化合物或其馏分的百合科植物的提取物，可用作高血糖改善剂的活性成分。
• DRUGS, FOOD OR DRINK FOR IMPROVING PANCREATIC FUNCTIONS
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1882477A1

  公开（公告）日：2008-01-30

  3-O-β-D-Glucopyranosyl-4-methyl-ergost-7-en-3-ol or a composition containing 0.001 to 10% by dry mass of the aforementioned compound, which is an extract of a plant of the family Liliaceae or a fraction thereof containing the compound, is used as an active ingredient of a drug for improving pancreatic functions.

  3-O-β-D-吡喃葡萄糖基-4-甲基麦角甾-7-烯-3-醇或含有 0.001%至 10%（以干质量计）上述化合物的组合物，是百合科植物的提取物或含有该化合物的馏分，可用作改善胰腺功能药物的活性成分。
• VISCERAL FAT ACCUMULATION INHIBITOR
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1927361A1

  公开（公告）日：2008-06-04

  To reduce amounts of fat accumulated in abdominal cavity and to prevent or ameliorate visceral fat type obesity considered to be a main factor of metabolic syndrome, there is provided an agent or a food or drink, including as an active ingredient 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol, an organic solvent extract, a hot water extract, a squeezed liquid of a Liliaceae plant or a fraction thereof which contains the compound.

  为了减少腹腔中积聚的脂肪量，预防或改善被认为是代谢综合征主要因素的内脏脂肪型肥胖，提供了一种制剂或食品或饮料，包括作为活性成分的 3-O-β-D-吡喃葡萄糖基-4-甲基麦角甾-7-烯-3-醇、有机溶剂提取物、热水提取物、百合科植物的挤压液或其馏分，其中含有该化合物。
• AGENT FOR AMELIORATION OF INSULIN RESISTANCE
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1930013A1

  公开（公告）日：2008-06-11

  To inhibit production of adipocytokines, in particular, adipocytokines that elicit insulin resistance and to prevent onset of pathosis caused by the insulin resistance, or improve the pathosis, the present invention provides an agent or a food or drink which contains 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol, or an organic solvent extract, a hot water extract or a squeezed liquid of a plant of the family Liliaceae or a fraction thereof which contains the compound as an active ingredient.

  为了抑制脂肪细胞因子的产生，特别是抑制引起胰岛素抵抗的脂肪细胞因子的产生，防止胰岛素抵抗引起的病变或改善病变，本发明提供了一种药剂或一种食品或饮料，其中含有 3-O-β-D- 吡喃葡萄糖基-4-甲基麦角甾-7-烯-3-醇，或百合科植物的有机溶剂提取物、热水提取物或挤压液或其馏分，其中含有该化合物作为活性成分。
• ANTIOXIDANT
  申请人：Morinaga Milk Industry Co., Ltd.

  公开号：EP2377875A1

  公开（公告）日：2011-10-19

  To provide an antioxidant which is highly safe, inhibits oxidation of a biological component, in particular, a lipid, and is used as a drug, food or drink, a food additive, an external preparation for skin, or the like. The antioxidant contains 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol as an active ingredient.

  提供一种安全性高、可抑制生物成分（尤其是脂质）氧化并可用作药物、食品或饮料、食品添加剂、皮肤外用制剂或类似制剂的抗氧化剂。这种抗氧化剂的活性成分是 3-O-β-D-吡喃葡萄糖基-4-甲基麦角甾-7-烯-3-醇。