5-氯-N,N-二甲基吡嗪-2-胺 | 136309-13-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 5-氯-N,N-二甲基吡嗪-2-胺
• 英文名称: 5-chloro-N,N-dimethylpyrazin-2-amine
• CAS: 136309-13-2
• 化学式: C₆H₈ClN₃
• 分子量: 157.603
• InChiKey: LFUSMRMQLZUXEA-UHFFFAOYSA-N

物化性质

• 沸点：
  233.3±35.0 °C(Predicted)
• 密度：
  1.252±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5-二氯吡嗪 、 盐酸二甲胺 在 三乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 以66 %的产率得到5-氯-N,N-二甲基吡嗪-2-胺
  参考文献：
  名称：

  WO2023/92107

  摘要：

  公开号：

文献信息

• N-HETEROCYCLIC METHYLPROPYLAMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND GERMICIDES
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP1020441A1

  公开（公告）日：2000-07-19

  N-heterocyclicmethylpropylamine derivatives of formula (I): and acid addition salts thereof; wherein R1 represents hydrogen, halogen, alkyl, alkenyl, halogenated alkyl, alkoxy, halogenated alkoxy, hydroxyl, cyano, nitro, phenyl optionally having a substituent on a ring thereof or phenoxy; n represents an integer of 0-5; R2 represents a heterocycle containing at least one nitrogen atom as the hetero atom and optionally having a substituent on a ring thereof; and R3 represents hydrogen or C1-C5 alkyl.

  式(I)的 N-杂环甲基丙胺衍生物： 及其酸加成盐； 其中 R1 代表氢、卤素、烷基、烯基、卤代烷基、烷氧基、卤代烷氧基、羟基、氰基、硝基、可选择在其环上具有取代基的苯基或苯氧基；n 代表 0-5 的整数；R2 代表至少含有一个氮原子作为杂原子并可选择在其环上具有取代基的杂环；以及 R3 代表氢或 C1-C5 烷基。
• N-(HETEROCYCLE-METHYL)ALKYLAMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND BACTERICIDE
  申请人：Kureha Chemical Industry Co., Ltd.

  公开号：EP1391450A1

  公开（公告）日：2004-02-25

  A N-heterocyclicmethyl-alkylamine derivative according to the present invention is a N-heterocyclicmethyl-alkylamine derivative represented by the following general formula (I): or an acid addition salt thereof. [in the formula, R1 represents a heterocycle which has at least one nitrogen atom as a hetero atom and may have a substituent on a ring; R2 represents a hydrogen or the like; R3 represents an alkyl group having a carbon number of 1 to 5 or the like; R4 represents an alkyl group having a carbon number of 1 to 5 or the like; when R4 is an alkyl group having a carbon number of 1 to 5 or a halogenated alkyl group having a carbon number of 1 to 5, carbon atoms in R3 and R4 may be bonded to form a ring structure; m represents an integer of 1 to 3; R5 represents a cycloalkyl group or the like described by the following formula (III): (in the formula, Y and Z each represents a hydrogen atom or the like, the letter p represents an integer of 2 to 5, and the groups described by CYZ may be each the same or different), when m is 1 and R4 is a hydrogen atom, R5 is a cycloalkyl group describedby the foregoing formula (III).]

  根据本发明，N-杂环甲基-烷基胺衍生物是由以下通式（I）代表的 N-杂环甲基-烷基胺衍生物： 或其酸加成盐。 [式中，R1 代表杂环，该杂环至少有一个氮原子作为杂原子，并可在环上有取代基；R2 代表氢或类似物；R3 代表碳原子数为 1 至 5 的烷基或类似物；R4 代表碳原子数为 1 至 5 的烷基或类似物；当 R4 是碳原子数为 1 至 5 的烷基或碳原子数为 1 至 5 的卤代烷基时，R3 和 R4 中的碳原子可以键合形成环状结构；m 代表 1 至 3 的整数；R5 代表下式（III）所述的环烷基或类似基团： (式中，Y 和 Z 分别代表氢原子或类似物，字母 p 代表 2 至 5 的整数，CYZ 所述基团可以相同或不同)，当 m 为 1 且 R4 为氢原子时，R5 为前式(III)所述的环烷基]。
• N-(heterocycle-methyl)alkylamine derivative, process for producing the same, and bactericide
  申请人：Ito Atsushi

  公开号：US20050101783A1

  公开（公告）日：2005-05-12

  A N-heterocyclicmethyl-alkylamine derivative according to the present invention is a N-heterocyclicmethyl-alkylamine derivative represented by the following general formula (I): or an acid addition salt thereof. [in the formula, R 1 represents a heterocycle which has at least one nitrogen atom as a hetero atom and may have a substituent on a ring; R 2 represents a hydrogen or the like; R 3 represents an alkyl group having a carbon number of 1 to 5 or the like; R 4 represents an alkyl group having a carbon number of 1 to 5 or the like; when R 4 is an alkyl group having a carbon number of 1 to 5 or a halogenated alkyl group having a carbon number of 1 to 5, carbon atoms in R 3 and R 4 may be bonded to form a ring structure; m represents an integer of 1 to 3; R 5 represents a cycloalkyl group or the like described by the following formula (III): (in the formula, Y and Z each represents a hydrogen atom or the like, the letter p represents an integer of 2 to 5, and the groups described by CYZ may be each the same or different), when m is 1 and R 4 is a hydrogen atom, R 5 is a cycloalkyl group described by the foregoing formula (III).]

  根据本发明，N-杂环甲基-烷基胺衍生物是由以下通式（I）代表的 N-杂环甲基-烷基胺衍生物： 或其酸加成盐。 [式中，R 1 代表至少有一个氮原子作为杂原子的杂环，并可在环上有取代基；R 2 代表氢或类似物；R 3 代表碳原子数为 1 至 5 的烷基或类似物； R 4 代表碳原子数为 1 至 5 的烷基或类似物；当 R 4 是碳原子数为 1 至 5 的烷基或碳原子数为 1 至 5 的卤代烷基时，R 3 和 R 4 中的碳原子可以键合形成环状结构；m 代表 1 至 3 的整数；R 5 代表下式（III）所述的环烷基或类似基团： (式中，Y 和 Z 分别代表氢原子或类似物，字母 p 代表 2 至 5 的整数，CYZ 所述基团可以相同或不同），当 m 为 1 且 R 4 是氢原子时，R 5 是前述式 (III) 所述的环烷基]。
• US6271385B1
  申请人：——

  公开号：US6271385B1

  公开（公告）日：2001-08-07
• [EN] INHIBITORS OF HEPATITIS C VIRUS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：PRESIDIO PHARMACEUTICALS INC

  公开号：WO2013163466A1

  公开（公告）日：2013-10-31

  A class of compounds that inhibit Hepatitis C Virus (HCV) is disclosed, along with compositions containing the compound, and methods of using the composition for treating individuals infected with HCV. The invention is intended to include all isotopically labeled analogs of the compounds of the invention. Isotopes include those atoms having the same atomic number but different mass.