2-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)quinazolin-4(3H)one | 684276-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)quinazolin-4(3H)one
• 英文别名: 2-(2,2,5,5-tetramethyl-1H-pyrrol-3-yl)-3H-quinazolin-4-one
• CAS: 684276-24-2
• 化学式: C₁₆H₁₉N₃O
• 分子量: 269.346
• InChiKey: MLBKKQUSQQUALQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  53.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] QUINAZOLINONE-DERIVATIVES AND THEIR USE FOR PREPARATION OF PHARMACEUTICAL COMPOSITIONS HAVING PARP ENZYME INHIBITORY EFFECT<br/>[FR] DERIVES DE QUINAZOLINONE ET UTILISATION DE CEUX-CI DANS LA PREPARATION DE COMPOSITIONS PHARMACEUTIQUES POSSEDANT DES EFFETS INHIBITEURS D'ENZYME
  申请人：SUEMEGI BALAZS

  公开号：WO2004096779A1

  公开（公告）日：2004-11-11

  The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a DNA-repairing enzyme, poly(ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutical compositions for preventing or treating illnesses where PARP-inhibition yields a beneficial effect. In general formula (I) R1 stands for either hydrogen or a group of general formula (a); R2 stands for a) hydrogen or C1-6 alkyl group, if R1 is other than hydrogen, and b) if R1 is hydrogen, then R2 may be a group of general formula (b), (c) or (d). The subject of the present invention also embraces the preparation processes of the compounds described above.

  本发明的主题是喹唑啉衍生物及其药用可接受的盐，其一般公式为（I），抑制DNA修复酶，多聚（ADP-核糖）聚合酶（PARP），使其可用于制备用于预防或治疗PARP抑制产生有益效果的疾病的药物组合物。在一般公式（I）中，R1代表氢或一般公式（a）的组；R2代表a）氢或C1-6烷基，如果R1不是氢，以及b）如果R1是氢，那么R2可以是公式（b）、（c）或（d）的组。本发明的主题还包括上述化合物的制备过程。
• EP1622881A1
  申请人：——

  公开号：EP1622881A1

  公开（公告）日：2006-02-08
• QUINAZOLINONE-DERIVATIVES AND THEIR USE FOR PREPARATION OF PHARMACEUTICAL COMPOSITIONS HAVING PARP ENZYME INHIBITORY EFFECT
  申请人：Pécsi Tudomànyegyetem

  公开号：EP1622881B1

  公开（公告）日：2010-05-26
• Quinazolinone-derivatives and their use for preparation of pharmaceutical compositions having parp enzyme inhibitory effect
  申请人：Sumegi Balazs

  公开号：US20070042935A1

  公开（公告）日：2007-02-22

  The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a DNA-repairing enzyme, poly(ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutical compositions for preventing or treating illnesses where PARP-inhibition yields a beneficial effect. In general formula (I) R 1 stands for either hydrogen or a group of general formula (a); R 2 stands for a) hydrogen or C 1-6 alkyl group, if R 1 is other than hydrogen, and b) if R 1 is hydrogen, then R 2 may be a group of general formula (b), (c) or (d). The subject of the present invention also embraces the preparation processes of the compounds described above.
• US7994182B2
  申请人：——

  公开号：US7994182B2

  公开（公告）日：2011-08-09